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Microbiology > 53- Herpesviruses > Flashcards

53- Herpesviruses Flashcards

1
Q

What is the structure of the herpesviruses?

A

• Herpesviridae: dsDNA, enveloped, icosadeltahedral capsid (162 capsomeres).

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2
Q

HSV1- site of latency

A

trigeminal ganglia

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3
Q

HSV1- clinical presentation

A

cold sores

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4
Q

HSV1/2- lab Dx

A

Tzanck smear (scraping base of lesion, shows giant multinucleated cells and cowdry type A inclusion bides

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5
Q

HSV2- site of latency

A

sacral ganglia

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6
Q

HSV2- clinical presentation

A

genital herpes

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7
Q

VZV- site of latency

A

Dorsal root ganglia

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8
Q

VZV- clinical presentation of 1o infection

A

chickenpox

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9
Q

VZV- clinical presentation of 2o infection

A

shingles (zoster)

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10
Q

VZV- lab Dx

A

Tzanck smear (scraping base of lesion, shows giant multinucleated cells and cowdry type A inclusion bides

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11
Q

VZV- vaccines

A

Live attenuated vaccine (oka strain)

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12
Q

EBV-site of latency

A

B cells

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13
Q

EBV- clinical presentation

A

mononucleosis (heterophile +)

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14
Q

EBV- lab Dx

A

Downey cells (atypical lymphocytes), heterophile antibodies (nonspecific activation of B cells by EBV)

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15
Q

EBV- cancer

A

YES! B cell mitosis, immortal b cell line, can lead to burkitt’s/hodgkins lymphoma

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16
Q

CMV- site of latency

A

mononuclear cells

17
Q

CMV- clinical presentation

A

mononucleosis (heterophile -), cytomegalic inclusion disease

18
Q

CMV- lab Dx

A

The Owl’s Eye Cell (dense central basophilic intranuclear inclusion body

19
Q

HHV6- site of latency

A

mononuclear cells

20
Q

HHV6- clinical presentation

A

roseola

21
Q

HHV8- clinical presentation

A

kaposi’s sarcoma

22
Q

What clinical syndromes are associated with human herpes virus 6, 7 8?

A

• Roseolaviridae – childhood disease of roseola (rose colored rash on babies)

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