5/21/2014 Flashcards
subacute combined degeneration
degen of lat and post spinal columns - B12 deficiency, copper, or vit E deficiency.
MCV
mean corpuscular volume - average volume of red cells in a specimen
intracellular iron storage
ferritin
battery factories
lead exposure
shipyards
asbestosis
microcytic anemias
lead, thalassemias, RA
number of people with a genotype that express the phenotype
penetrance
varied degree of disease within the same genotype
variable expression
gag reflex
in by nine (glossopharyngeal) out by ten
hypoglossal nerve
XII - motor of the tongue
vagus afferent or efferent
efferent
pneumoconioses
coalworkers (anthracosis), silicosis, beryliosis, asbestosis
sandblasters
silicosis
aerospace industry
berylliosis
construction, plumbing, and shipyards
asbestosis
impaired phagolysosome formation by macrophages leads to increased risk of TB
silica
fibrosis of massive exposure to carbon dust
black lung
boutonniere deformaty
RA
carbon dust pneumoconiosis associated with
RA, caplan syndrome (basilar nodules on xray in addition to coal miners RA)
dactylitis - swelling of soft tissues between joints - interstitial fibrosis
sausage fingers - psoriatic arthritis
rheumatoid nodules surrounded by pigmented cells
specific for caplan syndrome
noncaseating granulomas in lungs, hilar nodes, and systemic organs.
sarcoidosis
sarcoidosis with pneumoconiosis
berylliosis
lung carcinoma is more common than mesothelioma in
asbestosis
xerostomia
sjogrens
AR low UGT activity and increased UCB under stress
gilbert syndrome
absense of UGT, increased UCB - fatal in infancy
Crigler-Najjar
AR deficient bilirubin canalicular transport protein, increased CB - dark liver
Dubin-Johnson
dubin-johnson with no liver discoloration
rotor syndrome
increase in both UCB and CB, dark urine
viral hep
increased CB
obstructive or Dubin-Johnson
abnormal development of 3 and 4th branchial pounches
digeorge
abnormal 3rd branchial arch
congenital pharyngocutaneous fistula
failure of migration of 1st branchial arch - AD
treacher collins
first line treatment of acute gout - cox inhibitor and prostaglandin synthesis impeded.
indomethacin - NSAIDS
block TNF, used in autoimmune diseases
Etanercept and Infliximab
depolymerization of microtubules, impaired chemotaxis and degranulation - acute gout tx
colchicine
xanthine oxidase inhibitor, prophylactic gout treatment
allopurinol
generates acetate in mitochondria
acealdehyde dehydrogenase
function of disulfiram
increased acetaldehyde
aromatase inhibitor
anastrazole
contraindicated in tx of breast cancer
estrogens
medical abortion drug
mifeprestone
medical stimulation of labor contraction and cervical dilation
Dinoprostone
