4.I Etiology - mutations and DNA repair system Flashcards
1
Q
What is a mutation?
A
CHange in the nucleotide sequence of the genome of a living organism, virus or extrachromosomal genetic element
2
Q
What is required of a genetic alteration for it to be considered a mutation?
A
Must be stable and heritable
3
Q
Do mutations always produce phenotypic effects?
A
No
4
Q
What is polymorphism?
A
If the frequency of variations in a population is >1%
5
Q
5 classes of mutations
A
Spontaneous
Due to DNA/RNA damage or error-prone polymerases
Due to DNA repair mechanisms
Due to mutagens
Due to insertion/deletion of mobile genetic elements
6
Q
What kind of mutation does nitrous acid cause?
A
Deamination
7
Q
A
