4B Diversity, Classification and Variation Flashcards
How is DNA passed on from one generation to the next?
By gametes
What are gametes?
The sperm cells in males and egg cells in females
What is a zygote?
When a sperm cell fertilises an egg cell, the zygote divides and develops into a new organism
How many chromosomes do normal body cells have?
They have the diploid number (2n)
What does the ‘diploid number’ mean?
It means each cell contains two of each chromosome, one from the mum and one from the dad
How many chromosomes do gametes have?
The haploid number (n)
What does the ‘haploid number’ mean?
There’s only one copy of each chromosome
How is the diploid number of chromosomes achieved?
At fertilisation, a haploid sperm fuses with a haploid egg, making a cell with the normal diploid number of chromosomes
Half the chromosomes are from the father (the sperm) and half are from the mother (egg)
How is fertilisation random?
During sexual reproduction, any sperm can fertilise any egg
How does random fertilisation affect the zygotes?
It produces zygotes with different combinations of chromosomes to both parents
How does random fertilisation affect diversity?
The mixing of genetic material in sexual reproduction increases genetic diversity within a species
How are gametes formed?
Via meiosis
What is meiosis and where does it take place?
It is a type of cell division and it takes place in the reproductive organs
Why is meiosis necessary for gametes?
Cells that divide by meiosis are diploid to star with, but the cells formed from meiosis are haploid (halved)
Without meiosis you’d have double the no. chromosomes when the gametes are fused which would not be good
What happens in the first 2 stages of meiosis?
1) Before meiosis starts, the DNA unravels & replicates so there are two copies of each chromosome, called chromatids.
2) The DNA condenses to form double-armed chromosomes, each made from two sister chromatids. Sister chromatids are joined in the middle by a centromere.
What happens in Meiosis I (stages 3 & 4 of meiosis)?
3) (First division) - the chromosomes arrange themselves in homologous pairs
4) These homologous pairs are then separated, halving the chromosome number
What happens in Meiosis II (stages 5 & 6 of meiosis)?
5) (second division) - the pairs of sister chromatids that make up each chromosome are separated (the centromere is divided)
6) Four haploid cells (gametes) that are genetically different from each other are produced
How many cells are produced from meiosis?
4
When in Meiosis do the chromatids cross over?
In Meiosis I
How do the chromatids cross over in Meiosis I?
Homologous pairs of chromosomes come together & pair up
The chromatids twist around each other & bits of chromatids swap over
The chromatids still contain the same genes but now have a different combination of alleles
What are the cells like that meiosis produces?
They are genetically different
What are the two main events in meiosis that lead to genetic variation?
1 - Crossing over of chromatids
2 - Independent segregation of chromosomes
How does the crossing over of chromatids in meiosis create genetic variation?
The crossing over of chromatids in meiosis I means that each of the four daughter cells formed from meiosis contains chromatids with different alleles
How does independent segregation of chromosomes in meiosis create genetic variation?
1) Each homologous pair of chromosomes in your cells is made up of one chromosome from your mum (maternal) and one from your dad (paternal)
2) When the homologous pairs are separated in meiosis I, it’s completely random which chromosome from each pair ends up in which daughter cell
3) So the four daughter cells produced by meiosis have completely different combinations of those maternal and paternal chromosomes
4) This is called independent segregation (seperation) of the chromosomes
5) This ‘shuffling’ of chromosomes leads to genetic variation in any potential offspring
What are the stages of crossing over in meiosis?
1 - The chromosomes of homologous pairs come together
2 - Chromatids cross over
3 - One chromosome from each homologous pair ends up in each cell
4 - Each cell has a different chromatid and therefore a different set of alleles, which increases genetic variation
How are the number of chromosomes produced different in meiosis vs mitosis?
Mitosis –> Produces cells with the same no. chromosomes as the parent cell
Meiosis –> Produces cells with half the no. chromosomes as the parent cell
How is the genetic material produced different in meiosis vs mitosis?
Mitosis –> Daughter cells are genetically identical to each other and to the parent cell
Meiosis –> Daughter cells are genetically different from one another and the parent cell
How are the number of cells produced different in meiosis vs mitosis?
Mitosis –> Produces two daughter cells
Meiosis –> Produces four daughter cells
How many divisions do mitosis and meiosis involve?
Mitosis - one
Meiosis - two
Why can’t crossing over or independent segregation take place during mitosis?
There’s no pairing or separation of homologous chromosomes so they can’t cross over etc
This produces genetically identical daughter cells - unlike meiosis
What are chromosome mutations caused by?
Errors in cell division (during meiosis)
When an error in cell division occurs, how can this affect the chromosomes?
When meiosis goes wrong the cells produced can contain variations in the numbers of whole chromosomes or parts of chromosomes
What do chromosome mutations lead to?
Inherited conditions - because the errors are present in the gametes (the hereditary cells)
What is non-disjunction?
It’s a failure of the chromosomes to separate properly
What causes Down’s Syndrome in humans?
The non-disjunction of chromosome 21 during meiosis
Someone having an extra copy of chromosome 21
How does the non-disjunction of chromosome 21 cause someone to have Down’s Syndrome
It means that chromosome 21 fails to separate properly during meiosis - one cell will have an extra copy of 21 and another gets none
When the gamete with the extra copy fuses to another gamete at fertilisation, the resulting zygote will have 3 copies of chromosome 21
What are mutations?
Changes to the base sequence of DNA
What are the two types of mutations that can occur?
Substitution and deletion
What is a substitution mutation?
One base is substituted with another
e.g. AAGCT becomes ATGCT (A is swapped for T)
What is a deletion substitution?
One base is deleted
e.g. AAGCT becomes AGCT (A is deleted)
What does the order of DNA bases in a gene determine and how does a mutation affect this?
The particular protein that is going to be made
If a mutation occurs, the sequence may be changed and the protein formed could be altered
Do all mutations affect the order of the amino acid chain?
No - some substitutions and have no effect on the order
How does the degenerate nature of the genetic code affect mutations?
It means that some amino acids are coded for by more than one DNA triplet - therefore not all substitutions will change the amino acid sequence
e.g. TAT, TAC both code for tyrosine
Will substitutions always lead to a change in the amino acid sequence?
No - due to the degenerative nature of the genetic code, some amino acid sequences code for the same proteins so there can be no change
Will deletions always lead to a change in the amino acid sequence?
Yes - the deletion of a base will change the number of bases present, which will cause a shift in all the base triplets after it
What are mutagenic agents?
They increase the rate of mutation
Mutations occur randomly, however some things can cause an increase in the rate of mutations