4910:C7 Fluid & Electrolyte Balance Flashcards
arginine vasopressin (AVP)
aka antidiuretic hormone. Hormone produced n the pituitary. Acts on renal tubules to reduce urine output in response to dehydration or hyperosmolarity.
ascites
abnormal accumulation of fluid in the abdominal cavity.
colloid osmotic pressure
(oncotic pressure) The osmotic pressure attributed to proteins and other macromolecules.
colloid
a substance microscopically dispersed throughout another substance. Do not form a true solution.
cyclosporine
an immunosuppressant drug
diabetes insipidus
chronic excretion of very large amounts of pale urine of low specific gravity. Pituitary does not produce vasopressin and so kidneys do not reabsorb water.
diuresis
Production of excessive amounts of urine
facultative urine
excess water that is excreted through urine
hyperosmolar hyperglycemic nonketotic syndrome
A complication of type 2 DM, usually develops after period of hyperglycemia combined with inadequate fluid intake
insensible losses
fluid loss that cannot be easily measured, usually through sweat and respiration. ∿600-1000 mL/day. Is increased by fever, exercise, hyperventilation.
leukocytosis
high white blood cell count. Maybe result of hyperkalemia.
metabolic water
Water that is produced through nutrient metabolism.
obligatory urine
∿500mL. Required to excrete waste products & solutes.
osmolality
the number of osmols per kg of solvent
osmolarity
the number of osmols per liter of solution.
paresthesias
symptoms of tingling in fingers and toes; often consistent with electrolyte imbalance.
rales
Abnormal respiratory sounds made when air flows through liquid present in airways.
specific gravity
the weight of a solution in comparison to an equal amount of distilled water; used to measure the concentrating ability of the kidney.
thrombocytosis
low number of platelets. Maybe result of hyperkalemia.
Total Body Water
Adult Males: 60% BW; Adult Females: 50% BW; Infants: 60-80% BW(dependent on age – highest in premature infants).
Why women have a lower proportion of body water than men?
Body water is lower with decreased muscle mass and increased body fat. Also a person who is obese contains less water than if her or she were of normal weight. Water content also varies with age – a newborn infant is 70-75% water – an amount which decreases progressively with age. If an adult maintains a constant weight of 70 kg., body water will decrease about 1 kg per decade.
2/3 rule
The interstitial space contains about two-thirds of the extracellular volume.
Water free mass =
The “flesh” represents, on average, one third of the body volume. The remaining two-thirds in a normal weight individual represent water volume.
Total body water breakdown
Approximately 2/3ds of the total body water is contained in the intracellular space, with the remaining third in the extracellular compartment. This latter space is further subdivided into the interstitial and the vascular spaces. In a normal individual, the interstitial space contains about two-thirds of the extracellular V. The vascular space, the smallest of the body’s fluid compartments, represents approximately onethird of the extracellular V and about one-ninth of the body’s water space overall.
Extracellular fluid compartments
Interstitial, intravascular, & transcellular
Transcellular
Fluids found in secretions with in organs: GI secretion, CSF, & intraocular fluid
Third spaces
Peritoneal, pericardial, thoracic, joints, bursae
Normal osmolality of the blood
280-320 mOsm/kg H2O. Estimation of blood osmolality uses Na, K, glucose, urea
Normal osmolality of the GI tract
300 mOsm
How to calculate mOsm
mOsm = atomic wt in mg ÷ particles exerting osmotic pressure
dehydration
Deficit of water in the body. Cells become dehydrated when exposed to hypertonic solutions
Renal solute load (RSL)
minimum of 600-700 mOsm/day. Requires 500mL of obligatory urine. =(g protein x 5.7) + mEq (Na + k + Cl)