4103FSBMOL - Practical 1 - Colour Tests and Melting Point Determination of Adulterants.

Question 1

What is the main role of Adulterants when used to cut illicit drugs?

Answer 1

To reduce or mask the purity of a drug and to increase the profits made by drug dealers.

Question 2

Give some Examples of Adulterants which can be used?

Answer 2

• Aspirin.
• Paracetamol.
• Caffeine.
• Starch.
• Sugar.

Question 3

Name the 8 Examples of the Colour Tests which we used in Practical 1 to identify Adulterants?

Answer 3

• Ferric Chloride Test.
• Iodine Test.
• Libermann’s Test.
• Marquis Test.
• Amalic Test.
• Mandelin’s Test.
• Mecke’s Test.
• Froehde’s Test.

Question 4

What is the Ferric Chloride Test used for?

Answer 4

To test for Salicylates and Phenol containing groups.

Question 5

What is the Iodine Test used for?

Answer 5

To test for Starch.

Question 6

What is the Libermann’s Test used for?

Answer 6

To test for Phenols and Amines.

Question 7

What is the Marquis Test used for?

Answer 7

To test for Alkaloids, non-alkaloids, opioids and Methamphetamine.

Question 8

What is the Amalic Test used for?

Which Adulterant does is this Test used to determine?

Answer 8

To test for xanthines.

Positive Test for Caffeine.

Question 9

What is the Mandelin’s Test used for?

Answer 9

To test for Steroids, Alkaloids and Aspirin.

Question 10

What is the Mecke’s Reagent Test used for?

Answer 10

To test for Opium Alkaloids.

Question 11

What is the Froehde’s Test used for?

Answer 11

To test for Codeine, Opium and LSD.

Question 12

Which is the only test which has to go before any other test?

Answer 12

Marquis Test.

Question 13

Which is the only test that has to be completed in a fume hood?

Why?

Answer 13

Amalic Acid Test.

It produces toxic fumes which can’t be inhaled!

Question 14

What are the name of the crystals added in the Amalic Test?

Answer 14

Potassium Chlorate Crystals.

Question 15

What steps take place in the Amalic Test?

Answer 15

1. Add Amalic Reagent.
2. Add some Potassium Chlorate crystals.
3. Evapourate to Dryness.
4. Add Ammonium Hydroxide.

Question 16

What obeservations can be seen when the Ferric Chloride Test is added to Aspirin?

Answer 16

No colour change/ reaction.

Question 17

What obeservations can be seen when the Iodine Test is added to Aspirin?

Answer 17

No colour change/ reaction.

Question 18

What obeservations can be seen when the Libermann’s Test is added to Aspirin?

Answer 18

Colourless to Brown colour change.

Question 19

What obeservations can be seen when the Marquis Test is added to Aspirin?

Answer 19

No colour change/ reaction.

Question 20

What obeservations can be seen when the Amalic Test is added to Aspirin?

Answer 20

Addition of Potassium Chloride = yellow, after evaporation = orange/yellow, after addition of ammonium hydroxide = brown.

Question 21

What obeservations can be seen when the Mandelin’s Test is added to Aspirin?

Answer 21

Black colour formed.

Question 22

What obeservations can be seen when the Mecke’s Test is added to Aspirin?

Answer 22

Slight Beige Colour formed.

Question 23

What obeservations can be seen when the Froehde’s Test is added to Aspirin?

Answer 23

Purple Crystals were formed.

Question 24

What obeservations can be seen when the Ferric Chloride Test is added to Paracetamol?

Answer 24

Dark Moudly Green Colour Formed.

Question 25

What *obeservations* can be seen when the **Iodine Test is added to Paracetamol?**

Answer 25

No colour change/ reaction.

Question 26

What *obeservations* can be seen when the **Libermann's Test is added to Paracetamol?***

Answer 26

**Brown/ Black** Colour Formed.

Question 27

What *obeservations* can be seen when the **Marquis Test is added to Paracetamol?**

Answer 27

No colour change/ reaction.

Question 28

What *obeservations* can be seen when the **Amalic Test is added to Paracetamol?**

Answer 28

Addition of Potassium Chloride = **yellow**, after evaporation = **orange/yellow**, after addition of ammonium hydroxide = **brown.**

Question 29

What *obeservations* can be seen when the **Mandelin's Test is added to Paracetamol?**

Answer 29

**Brown/ Green** Colour Formed.

Question 30

What *obeservations* can be seen when the **Mecke's Test is added to Paracetamol?**

Answer 30

No colour change/ reaction.

Question 31

What *obeservations* can be seen when the **Froehde's Test is added to Paracetamol?**

Answer 31

**Light Blue** Colour Formed.

Question 32

What *obeservations* can be seen when the **Ferric Chloride Test is added to Caffeine?**

Answer 32

No colour change/ reaction.

Question 33

What *obeservations* can be seen when the **Iodine Test is added to Caffeine?**

Answer 33

No colour change/ reaction.

Question 34

What *obeservations* can be seen when the **Libermann's Test is added to Caffeine?**

Answer 34

**Light Yellow** Colour Formed.

Question 35

What *obeservations* can be seen when the **Marquis Test is added to Caffeine?**

Answer 35

No colour change - slight cloudiness.

Question 36

What *obeservations* can be seen when the **Amalic Test is added to Caffeine?**

Answer 36

Addition of Potassium Chloride = **yellow**, after evaporation = **orange/brown**, after addition of ammonium hydroxide = **pink/purple.**

Question 37

What *obeservations* can be seen when the **Mandelin's Test is added to Caffeine?**

Answer 37

No colour change/ reaction.

Question 38

What *obeservations* can be seen when the **Mecke's Test is added to Caffeine?**

Answer 38

No colour change/ reaction.

Question 39

What *obeservations* can be seen when the **Froehde's Test is added to Caffeine?**

Answer 39

No colour change/ reaction.

Question 40

What *obeservations* can be seen when the **Ferric Chloride Test is added to Starch?**

Answer 40

No colour change/ reaction.

Question 41

What *obeservations* can be seen when the **Iodine Test is added to Starch?**

Answer 41

**Blue/Black** Colour Formed.

Question 42

What *obeservations* can be seen when the **Libermann's Test is added to Starch?**

Answer 42

No colour change/ reaction.

Question 43

What *obeservations* can be seen when the **Marquis Test is added to Starch?**

Answer 43

No colour change/ reaction.

Question 44

What *obeservations* can be seen when the **Amalic Test is added to Starch?**

Answer 44

Dissolved in HCl, **Yellow** on the addition of Potassium Chlorate crystals. After evapouration = **colourless**, after addition of ammonium hydroxide = **colourless**.

Question 45

What *obeservations* can be seen when the **Mandelin's Test is added to Starch?**

Answer 45

No colour change/ reaction.

Question 46

What *obeservations* can be seen when the **Mecke's Test is added to Starch?**

Answer 46

**Light Beige** Colour Formed.

Question 47

What *obeservations* can be seen when the **Froehde's Test is added to Starch?**

Answer 47

No colour change/ reaction.

Question 48

What *obeservations* can be seen when the **Ferric Chloride Test is added to Sugar?**

Answer 48

No colour change/ reaction.

Question 49

What *obeservations* can be seen when the **Iodine Test is added to Sugar?**

Answer 49

No colour change/ reaction.

Question 50

What *obeservations* can be seen when the **Libermann's Test is added to Sugar?**

Answer 50

No colour change/ reaction.

Question 51

What *obeservations* can be seen when the **Marquis Test is added to Sugar?**

Answer 51

**Light Yellow** Colour Formed.

Question 52

What *obeservations* can be seen when the **Amalic Test is added to Sugar?**

Answer 52

Addition of Potassium Chloride = **yellow**, after evaporation = **brown** residue, after addition of ammonium hydroxide = **brown.**

Question 53

What *obeservations* can be seen when the **Mandelin's Test is added to Sugar?**

Answer 53

No colour change/ reaction.

Question 54

What *obeservations* can be seen when the **Mecke's Test is added to Sugar?**

Answer 54

No colour change/ reaction.

Question 55

What *obeservations* can be seen when the **Froehde's Test is added to Sugar?**

Answer 55

No colour change/ reaction.