4

Question 1

What is molitin released from and what stimualtes its release?

Answer 1

Released from M cells

Fasting stimulates it and it is released in 100 min intervals

• Release is under neural control (acid and fat can also
• cause small amounts to be released)

Question 2

What does motilin to in relation to motility?

Answer 2

Stimulates upper GI motility

Accounts for the migrating motility complexes

Question 3

Where is somatostatin found and what stimulates its release?

Answer 3

Found in gastric/duodenal mucosa and pancreas
- Release—stimulated by acid, inhibited by Ach

Question 4

What does somatostatin inhibit?

Answer 4

Inhibits release of all gut hormones
- Directly inhibits parietal cell acid secretion
- Mediates acid-induced inhibition of gastrin release

Question 5

What stimulates the release of histamine?

Answer 5

Gastrin and Ach cause release from cellsin the stomach

Question 6

What does histamine stimulate?

Answer 6

The release of gastric acid

Question 7

What are examples of histamine (H2) receptor blockers and what do they do?

Answer 7

• • Cimetidine (Tagamet), Ranitidine (Zantac)

Decrease the release of acid

Question 8

What is the location of the neurocrines: VIP, GRP, Enkephalins?

Answer 8