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Question 1

What is gastrin inhibted by?

Answer 1

Secretion is inhibited by acidification of antrum

Question 2

What does gastrin stimulate?

Answer 2

Gastrin stimulates pyloric contraction and increases cardiac sphincter tone, preventing
reflux. Gastrin also stimulates acid and pepsinogen secretion and antral motility, thus
facilitating gastric digestion

Question 3

How does gastrin effect the mucosa?

Answer 3

Stimulates growth of oxyntic mucosa of the stomach, the duodenal mucosa, and colonmucosa
Surgical removal ofthe antrum causes atrophy.

Question 4

What do patients with gastrinomas have in relation to the mucosa?

Answer 4

Patients with gastrin-secreting tumors have mucosal hyperplasia and hypertrophy.

Question 5

What does CCK do in relation to sphinchers and enzymes?

Answer 5

Contraction of pyloric
sphincter and inhibition
of gastric emptying

↑ pancreatic
secretion of enzymes

↑ glucagon secretion

Augments the secretin effect
on secretion of bicarbonate
in the pancreas and liver

Question 6

What kinase does CCK increase the secretion of?

Answer 6

Enterokinase

Question 7

In what conditions does cck have maximal effect?

Answer 7

Normal vagal tone and the prescence of secretin

Question 8

What does CCK do in relation to the gall bladder?

Answer 8

Gallbladder contraction, emptying
of the gallbladder and relaxation of
the sphincter of Oddi

Question 9

What does secretin do in realtion with the spintchers and secretion?

Answer 9

May stimulate the contraction of the pyloric spintcher

Inhibts the secretion of HCL and gastric motility

Inhibits gastrin release as well as gastric acid secretion
(enterogastrone) - Stimulates pancreatic and bile bicarbonate secretion - Stimulates pepsin secretion
- Trophic effect on exocrine pancreas

Question 10

What does secretin do in relation with CCK

Answer 10

Augments its action on the pancreas and antagonises gastrin