3rd semester 2nd MT

Question 1

Which protease are responsible for the destruction of the intrinsic tenase and the prothrombinase complexes?

Answer 1

Thrombin

Protein C

Question 2

Which protein co factors are responsible for the destruction of the intrinsic tenase and the prothrombinase complexes?

Answer 2

Thrombomodulin

Pritein S

Question 3

Throughput of K+ ch

Answer 3

1-2x10^8

Question 4

What carries the most info on the memb. Topology of an ion ch?

Answer 4

Hydropathy plot

Question 5

Streptokinase mechanism

Answer 5

Human plasminogen in a complex with streptokinase becomes a plasminogen activator

Question 6

What is the mode of antifibrinolytic action of TAFIa?

Answer 6

Cleaves C terminal Lys residues -> decreases the binding site for the tPA and plasminogen in fibrin and moderates the cofactor function of fibrin in plasminogen activation

Question 7

Coumarin effect, in what drug is it present?

Answer 7

Warfarin

Decreases blood clotting by blocking an enzyme called vitamin K epoxide reductase that reactivates vitamin K

Question 8

When do Ca ch. permits Na entrance?

Answer 8

When Ca conc is decreased

Question 9

How does thrombin activates platelets?

Answer 9

Hydrolysis of memb. Proteins

Increasing cytosolic Ca conc.

Question 10

tPA job?

Answer 10

Protein involved in the breakdown of blood clots

Catalyzes plasminogen -> plasmin

Question 11

K+ ch structure

Answer 11

Tetramer

Question 12

What stabilizes fVIII?

Answer 12

vWf

Question 13

What is the role of TXA2 and what cell produces it?

Answer 13

Pro thrombotic effect

Produced by activated platelets

Question 14

Structure of ATP sens. K+ ch

Answer 14

Octamer
4 kir6.2
4 SUR

Question 15

Thrombaxane is inhibited by

Answer 15

Aspirin

Question 16

NO will lead to?

Answer 16

Vasodilation

Increased blood flow

Question 17

2 functions of vWf?

Answer 17

Carrier of fVIII

Mediator of platelet adhesion at high shear

Question 18

Synthesis of NO starts from?

Answer 18

Arg

Question 19

What activates protein C?

Answer 19

Thrombomodulin bound thrombin

Question 20

What is the mode of activation of streptokinase?

Answer 20

Forms a complex with human plasminogen in which plasminogen gains activity as plasminogen activator

Question 21

How does thrombomodulin modify blood coagulation?

Answer 21

Accelerates protein C activation by thrombin

Question 22

What stimulates tPA?

Answer 22

Fibrin

Question 23

Hemophilia B is caused by deficiency in?

Answer 23

fIX

Question 24

Anti-phospholipid syndrome can be treated with (2)

Answer 24

Vit K antagonist

Heparin

Question 25

What is the background of activated protein C resistance?

Answer 25

Arg 506 in fV is mutated

Question 26

What can be a substrate for thrombin?

Answer 26

``` Fibrinogen V VIII XI XIII Platelets ```

Question 27

Because_________ is inhibited by Aspirin, there is no production of _______ and _________

Answer 27

COX TXA2 PGI2

Question 28

What will deficiency in vit K leads to?

Answer 28

Reduces protein C levels | Reduces prothrombin levels

Question 29

Actions of Heparin?

Answer 29

Facilitates thrombin inactivation by antithrombin

Question 30

Where is the pore loop located?

Answer 30

Extracellularly

Question 31

Effect of Sulfonylurea on ATP sensitive K channels, where do they bind?

Answer 31

Inhibit the ch -> depol -> insulin secretion | Binds SUR1

Question 32

Ion ch are stochastic or deterministic?

Answer 32

Stochastic

Question 33

How is fibrinolysis terminate?

Answer 33

a2 plasmin inhibitor inactivates plasmin

Question 34

How can tPA activity increase?

Answer 34

In the presence of fibrin

Question 35

List 3 plasminogen activators used in therapy?

Answer 35

tPA uPA Streptokinase

Question 36

3 phases of platelets activation:

Answer 36

1. Adhesion 2. Activation 3. Aggregation

Question 37

Antithrombotic effects of thrombin?

Answer 37

Thrombin-TM complex activates protein C which will inhibit fV and fVIII

Question 38

Substrates for factor VIIa?

Answer 38

fX | fIX

Question 39

Structural consequence of coumarine?

Answer 39

Inhibition of Gla domain formation

Question 40

ecto ATPase activity?

Answer 40

Inhibition of platelets activation

Question 41

What are the vit K dependent factors?

Answer 41

II VII IX X

Question 42

What is TAFI (Thrombin Activatable Fibrinolysis Inhibitor)

Answer 42

Carboxypeptidase

Question 43

What activates TAFI?

Answer 43

Thrombin-TM complex

Question 44

TAFI action?

Answer 44

Reduces fibrinolysis by removing the C terminal residues that are important for the binding and activation of plasmin

Question 45

hirudin action?

Answer 45

inhibits thrombin directly

Question 46

how can the activity of tPA be increased?

Answer 46

in the presence of fibrin

Question 47

location of CFRT?

Answer 47

apical side of endothelial cells

Question 48

describe each hemophilia A B C

Answer 48

A- fVIII B- fIX C- XI

Question 49

what is the most frequent cause of hemophilia?

Answer 49

Antiphospholipid syndrome

Question 50

where can we find Gla-domain?

Answer 50

``` II VII IX X protein C, Z, S ```

Question 51

when will we give hirudin?

Answer 51

when a persim lacks antithrombin

Question 52

what factor inhibits plasmin and how?

Answer 52

fXIIIa | makes Gln-Lys isopeptide bonds btw a2-antiplasmin and plasmin