Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

S.N Biochemistry 3 > 3rd semester 2nd MT > Flashcards

3rd semester 2nd MT Flashcards

1
Q

Which protease are responsible for the destruction of the intrinsic tenase and the prothrombinase complexes?

A

Thrombin

Protein C

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Which protein co factors are responsible for the destruction of the intrinsic tenase and the prothrombinase complexes?

A

Thrombomodulin

Pritein S

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Throughput of K+ ch

A

1-2x10^8

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What carries the most info on the memb. Topology of an ion ch?

A

Hydropathy plot

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Streptokinase mechanism

A

Human plasminogen in a complex with streptokinase becomes a plasminogen activator

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is the mode of antifibrinolytic action of TAFIa?

A

Cleaves C terminal Lys residues -> decreases the binding site for the tPA and plasminogen in fibrin and moderates the cofactor function of fibrin in plasminogen activation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Coumarin effect, in what drug is it present?

A

Warfarin

Decreases blood clotting by blocking an enzyme called vitamin K epoxide reductase that reactivates vitamin K

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

When do Ca ch. permits Na entrance?

A

When Ca conc is decreased

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

How does thrombin activates platelets?

A

Hydrolysis of memb. Proteins

Increasing cytosolic Ca conc.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

tPA job?

A

Protein involved in the breakdown of blood clots

Catalyzes plasminogen -> plasmin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

K+ ch structure

A

Tetramer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What stabilizes fVIII?

A

vWf

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What is the role of TXA2 and what cell produces it?

A

Pro thrombotic effect

Produced by activated platelets

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Structure of ATP sens. K+ ch

A

Octamer
4 kir6.2
4 SUR

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Thrombaxane is inhibited by

A

Aspirin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

NO will lead to?

A

Vasodilation

Increased blood flow

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

2 functions of vWf?

A

Carrier of fVIII

Mediator of platelet adhesion at high shear

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Synthesis of NO starts from?

A

Arg

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

What activates protein C?

A

Thrombomodulin bound thrombin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

What is the mode of activation of streptokinase?

A

Forms a complex with human plasminogen in which plasminogen gains activity as plasminogen activator

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

How does thrombomodulin modify blood coagulation?

A

Accelerates protein C activation by thrombin

22
Q

What stimulates tPA?

A

Fibrin

23
Q

Hemophilia B is caused by deficiency in?

A

fIX

24
Q

Anti-phospholipid syndrome can be treated with (2)

A

Vit K antagonist

Heparin

25
Q

What is the background of activated protein C resistance?

A

Arg 506 in fV is mutated

26
Q

What can be a substrate for thrombin?

A 
Fibrinogen
V
VIII
XI
XIII
Platelets
27
Q

Because_________ is inhibited by Aspirin, there is no production of _______ and _________

A

COX
TXA2
PGI2

28
Q

What will deficiency in vit K leads to?

A

Reduces protein C levels

Reduces prothrombin levels

29
Q

Actions of Heparin?

A

Facilitates thrombin inactivation by antithrombin

30
Q

Where is the pore loop located?

A

Extracellularly

31
Q

Effect of Sulfonylurea on ATP sensitive K channels, where do they bind?

A

Inhibit the ch -> depol -> insulin secretion

Binds SUR1

32
Q

Ion ch are stochastic or deterministic?

A

Stochastic

33
Q

How is fibrinolysis terminate?

A

a2 plasmin inhibitor inactivates plasmin

34
Q

How can tPA activity increase?

A

In the presence of fibrin

35
Q

List 3 plasminogen activators used in therapy?

A

tPA
uPA
Streptokinase

36
Q

3 phases of platelets activation:

A
  1. Adhesion
  2. Activation
  3. Aggregation
37
Q

Antithrombotic effects of thrombin?

A

Thrombin-TM complex activates protein C which will inhibit fV and fVIII

38
Q

Substrates for factor VIIa?

A

fX

fIX

39
Q

Structural consequence of coumarine?

A

Inhibition of Gla domain formation

40
Q

ecto ATPase activity?

A

Inhibition of platelets activation

41
Q

What are the vit K dependent factors?

A

II
VII
IX
X

42
Q

What is TAFI (Thrombin Activatable Fibrinolysis Inhibitor)

A

Carboxypeptidase

43
Q

What activates TAFI?

A

Thrombin-TM complex

44
Q

TAFI action?

A

Reduces fibrinolysis by removing the C terminal residues that are important for the binding and activation of plasmin

45
Q

hirudin action?

A

inhibits thrombin directly

46
Q

how can the activity of tPA be increased?

A

in the presence of fibrin

47
Q

location of CFRT?

A

apical side of endothelial cells

48
Q

describe each hemophilia
A
B
C

A

A- fVIII
B- fIX
C- XI

49
Q

what is the most frequent cause of hemophilia?

A

Antiphospholipid syndrome

50
Q

where can we find Gla-domain?

A 
II
VII
IX
X
protein C, Z, S
51
Q

when will we give hirudin?

A

when a persim lacks antithrombin

52
Q

what factor inhibits plasmin and how?

A

fXIIIa

makes Gln-Lys isopeptide bonds btw a2-antiplasmin and plasmin

S.N Biochemistry 3 (14 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions