Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

S.N Biochemistry 3 > 2nd semester > Flashcards

2nd semester Flashcards

1
Q

SGLT2 is responsible for ___ % of the glucose reabsorption

A

90%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

NADPH source

A

PPP
malic enzyme
isocitrate DH (Lerant lectures)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

what does phosphorylation of pyruvate kinase do?

A

inhibition of the enzyme

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

describe the reaction catalyzed by histidine Decarboxylase

A

Histidine->histamine +CO2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

write down the reaction catalyzed by alanine amino transferase:

A

alanine + a-KG -> pyruvat + glutamate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

amino acids that will be convertes to acetyl coA

A

TryIL! ט’ריל זה כמו מרגש עם שגיואת כתיב וזה גם מתחרז עם אסטיל
tryptohpahn
isoleucine
leucine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

which Apo activates LCAT

where can we find it?

A

Apo A1
HDL
(HDL has L in it like LCAT)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

enzymes of B Oxidation:

A 
thiokinase
acyl-co A DH (FADH2)
enoyl-coA hydratase
b-hydroxy-acyl-coA DH (NAH+H)
acyl coA-acetyl transferase
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

after getting propionyl coA from oxidation of odd number FA how do we continue?

A
  1. propionyl co A -> methylmalonyl co A (by propionyl co A carboxylase with biotin)
  2. methylmalonyl co A -> succinyl co A (by methylmalonyl co A mutase with B12)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

write down the reaction catalyzed by lactate DH

A

pyruvate + NADH + H -> lactate + NAD

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

amino acids that will be convertes to pyruvate

A 
Pirates Come And Go To The See 
cys
ser
ala (think about alanine aminotransferase)
gly
thr
try
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

biotin dependent carboxylase in human:

A

pyruvate carboxylase
acetyl coA carboxylase
propionyl coA carboxylase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

describe the sucrose bond

A

a-glucose1 -> 2b-fructose

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

what are the high energy phosphate compounds?

A

1,3-BPG

PEP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

what hormone contributes to the phosphorylation of PFK2-FBPase2?

A

glucagon (cAMP increases)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

which enzyme catalyze the reaction grom cholesterol to pregnenolone?

A

P450 SCC (side chain cleavage)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Km of GLUT2 ?

A

17 mM, very high!

so low affinity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

why 2,3-BPG is importent and where?

A

increase in 2,3-BPG conc -> decrease the affinity of Hg to O2
RBC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

write down the reaction catalyzed by phosphopentose isomerase

A

D-ribulose-5-P -> D-ribose-5-P

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

localization of Cyt P450 ?

A

mainly ER

or mitochondria

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

what is the location of SGLT1?

glucose affinity?

A

intestine
kidney

high affinity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

what is the location of the disaccharidases?

A

brush border enzymes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

molecules of TCA by order

A 
citrate is krebs starting substrate for making oxaloacetate
citrate
isocitrate
a-KG
succinyl coA
succinate
fumarate
malate
OAA
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

amino acids that will be convertes to OAA?

A

asparagine and aspartate (remember asp aminoatransferase)

both start with A and both have long name like OAA)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
write doen the reaction catalyzed by pyruvate DH?
pyruvate + NAD + coA-SH -> acetyl coA + CO2 + NADH +H
26
essential AA?
``` PVT TIM HALL phe (remmber we need it for tyrosine synthesis) val thr try (needed for serotonine!) iso his arginine (in Lerants lecture it is not essential) leu lys ```
27
what type of bond does amylase catalyze? | what is the product
a(1->4) glycosidic bond | dextrins, then a mixture of glucose, maltose
28
which lipoprotein contains the largest amount of proteins?
HDL3
29
what enzyme is deficient in essential fructosuria?
fructokinase | fructose -> F1P
30
lioproteins by order of density
``` chylo VLDL IDL LDL HDL ```
31
describe the maltose bond
a-1-glucose -> 4a-glucose
32
amino acids that will be convertes to acetoacetyl coA
``` LPL (like lpl and it is in contact with FA also acetoacetyl comes from there basically) TryTyr leu phe lys try tyr ```
33
what are the inhibitors of pyruvate kinase in the liver?
alanine and ATP
34
what is special about phosphorylated glycolytic intermediates?
cannot leave the cell
35
glycogenin recations (2)
1. transfer of glucose from UDP-glucose to glycogenin | 2. chain extending
36
what is blockes in galactosemia?
galactose-1-P uridylyl transferase enzyme
37
who is active when they are phosphorylated? | PFK2-FBPase2
FBPase2
38
write down the reaction catalyzed by aspartate amino transferase:
aspartate + a-KG -> OAA + glutamate
39
McArdle disease?
muscle phosphorylase | Mc-Muscle, same letter
40
localization of glucokinase?
liver | pancreatic b- cells (glucose sensor!)
41
write down all glycolysis enzymes
``` hexokinase phosphohexose-ispmerase PFK1 aldolase triose phosphate isomerase glyceraldehyde-3-P DH phosphoglycerate kinase phosphoglycerate mutase enolase pyruvate kinase ```
42
which Apo activates LPL?
Apo C-II
43
write down the reaction catalyzed by biphosphoglycerate mutase
1,3-BPG -> 2,3-BPG
44
what is the difference btw ACAT and LCAT
ACAT- formation of cholesteryl ester in cells, acyl donor is Acyl coA LCAT- formation of cholesteryl ester in lipoproteins, acyl donor is Lecitin (L-L same letter)
45
what is the location of SGLT2? | glucose affinity?
kidney low affinity
46
hints for carnitine structure
N in the midle of four C
47
what GLUT in RBC?
1
48
reaction catalyzed by aldolase B?
F1P -> glyceraldehyde + dihydroxyacetone -P
49
in what condition we will have high amount of free FA in the blood?
intensive exsesize | untreated diabetes mellitus
50
amino acids that will be convertes to succinyl coA?
``` I love MTV (רואים אםטיוי בסוכה שזה דמוה לסוכיניל) iso met thr val (also- Vallery Sucks Thor In Metro) ```
51
what are lipoproteins?
complex of lipids and proteins
52
which AA are both gluco- and keto- genic? | according to Lerant's lecture
``` Ty Is Phucking Trippy!! Tyrosine isoleucine Phenilalanine tryptophan ```
53
write down the reaction catalyzed by galactose-1-P uridylyl transferase
galactose-1-P + UDP-glucose -> glucose-1-P + UDP-galactose
54
how many ATP from the B oxidation of palmitoyl-coA?
``` 106 ATP (Lerant lecture) <108.5-2=106.5> ```
55
which AA are only keto- genic? | according to Lerant's lecture
Leu (לא!! אל תסתכלו עליי אני שמן!!) or LOSERS! (leu and lys)
56
what are the metabolic effects of LXR?
target genes include ABC A1- cholesterol efflux CYP7A1- bile synthesis IDOL (Inducible Degrador of LDL Receptor)
57
which lipoprotein contains the largest amount of cholesteryl-ester?
LDL
58
what does salivary/pancreatic amylase catalyze?
hydrolysis of starch and diatery glycogen
59
Von-Gierke disease?
glucose-6-phosphatase | von G its like G-6-Pase, same letter
60
describe the lactose bond
b-galactose-1 -> 4a-glucose
61
alanine aminotransferase reaction
alanine+aKG->pyruvate+glutamate
62
2 possible catabolic fates of pyruvate
acetyl coA | lactate
63
amino acids that will be convertes to a-KG
``` GAG PH gln arg (remember like ine suffix) glu pro his ```
64
carbohydrate malabsoption can lead to | due to deffect in brush border enzymes
osmotic diarrhea with low pH
65
which lipoprotein contains the largest amount of TAG?
chylomicrons
66
what is the essential cofactor in the glycogen phosphorylase reaction?
PLP
67
amino acids that will be convertes to fumarate?
PhAT (similar to fat and gumarate starts with f) phe asp tyr
68
how can we convert glycerol into a glycolytic intermediate?
1. glycerol + ATP -> glycerol-3-P + ADP (by glycerol kinase) | 2. glycerol-3-P +NAD -> dihydroxyacetone-P + NADH + H (by glycerol-P DH)
69
describe the structure of lipoprotein
core- non polar TAG and cholesteryl ester | out- phospholipids, cholesterol, Apo's
70
write down the enzymes of PPP
glucose-6-P DH lactonase 6-phosphogluconate DH phosphopentose isomerase

S.N Biochemistry 3 (14 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions