3RD BIMEX Flashcards
The hepatocytes in this area are the first to undergo fatty accumulation and ischemic
necrosis:
zone I
zone III
zone II
zone III
Abnormalities in Thyroid Functions
tiredness and decreased ability to concentrate
hypothyroidism
hyperthyroidism
hypothyroidism
Abnormalities in Thyroid Functions
nervousness & sweating
hypothyroidism
hyperthyroidism
hyperthyroidism
Abnormalities in Thyroid Functions
weight loss & heat intolerance
hypothyroidism
hyperthyroidism
hyperthyroidism
Catecholamines are produced by these organs:
adrenal medulla central nervous system adrenal cortex 1st & 2nd choices only All of the above
1st & 2nd choices only
These two organs in the body produce steroid hormones:
pituitary & adrenal glands
pancreas & kidneys
adrenal glands & gonads
pituitary & thyroid glands
adrenal glands & gonads
This is the LEAST description of hepatic lobules
A. made up of hundreds of irregular hepatocyte plates
around 2 mm in size
B. the hepatocyte plates are supported by a delicate stroma of reticulin fibers
C. plates are arranged radially around a small central bile duct
C. plates are arranged radially around a small central bile duct
These are the CORRECT directions of blood & bile flows:
A. Both blood & the bile flow from the center of the lobule to its periphery.
B. Blood flows from the periphery to center of hepatic lobule, while the bile flow from the center of the lobule to its periphery.
C. Bile flows from the periphery to center of hepatic lobule, while the blood flow from the center of the lobule to its periphery.
D. Blood & bile flows from the periphery to center of hepatic lobule
B. Blood flows from the periphery to center of hepatic lobule, while the bile flow from the center of the lobule to its periphery.
Most common stone in Cholelithiasis:
uric acid stone
cholesterol stones
brown or black pigment stones
cholesterol stones
This is the only digestive organ lined by a mucosa, but without an existing submucosal layer:
gallbladder
pancreas
liver
gallbladder
Gigantism & acromegaly are conditions that could result from a functional pituitary
adenomas involving these cells:
thyrotrophs
corticotrophs
somatotropic cells
gonadotrophs
somatotropic cells
Diffuse NeuroEndocrine System:
reduces sodium absorption by the kidney
Atrionatriuretic peptide (ANP)
Gastrin
Somatostatin
Secretin
Atrionatriuretic peptide (ANP)
Diffuse NeuroEndocrine System:
stimulates secretion of gastric acid (HCl) by the parietal cells
Atrionatriuretic peptide (ANP)
Gastrin
Somatostatin
Secretin
Gastrin
Diffuse NeuroEndocrine System:
stimulate pancreas & cholangiocytes to secrete
bicarbonate
Atrionatriuretic peptide (ANP)
Gastrin
Somatostatin
Secretin
Secretin
Diffuse NeuroEndocrine System:
inhibits insulin and glucagon secretion
Atrionatriuretic peptide (ANP)
Gastrin
Somatostatin
Secretin
Somatostatin
A 40y.o. female patient came in complaining of on & off feeling of head heaviness. At
times, she would have light-headedness & cold sweats, with cold clammy extremities.
Her BP on admission was 160/100, She was admitted and monitored every 6hours.
For the first 24hours, without any medications, her BP records show the following
findings: 120/80, 150/90, 80/50, 160/90. Give your clinical impression:
pituitary adenomas
pheochromocytoma
diabetes Insipidus
addison disease
pheochromocytoma
This is a thickening of the liver capsule at the hilum on the inferior side.
portal vein
hepatic septum
porta hepatis
porta hepatis
Effects of catecholamines EXCEPT:
dilatation of the pupils
lipolysis
hypoglycemia
increasing the blood pressure
hypoglycemia
Thyroid Follicular Activity:
ACTIVE OR RESTING
large amount of acidophilic colloid
Resting Follicle
Thyroid Follicular Activity:
ACTIVE OR RESTING
lined by squamous epithelium
Resting Follicle
Thyroid Follicular Activity:
ACTIVE OR RESTING
Follicles are small with more microvilli
Active Follicle
Thyroid Follicular Activity:
ACTIVE OR RESTING
Nucleus pale with scalloped colloid
Active Follicle
This forms 75% of the adenohypophysis and has a thin fibrous capsule.
pars intermedia
pars tuberalis
pars nervosa
pars distalis
pars distalis
Diffuse NeuroEndocrine System:
increases intestinal absorption of calcium, magnesium, and phosphate
Vit D3 & calcitriol
Relaxin
Human chorionicM gonadotropin (HCG)
Progesterone
Vit D3 & calcitriol
Diffuse NeuroEndocrine System:
Stimulate thickening of endometrium, producing the
decidua
Vit D3 & calcitriol
Relaxin
Human chorionicM gonadotropin (HCG)
Progesterone
Progesterone
Diffuse NeuroEndocrine System:
ripening of cervix & softening of pubic symphysis during labor
Vit D3 & calcitriol
Relaxin
Human chorionicM gonadotropin (HCG)
Progesterone
Relaxin
Diffuse NeuroEndocrine System:
decrease maternal immune response to allow acceptance of pregnancy
Vit D3 & calcitriol
Relaxin
Human chorionicM gonadotropin (HCG)
Progesterone
Human chorionicM gonadotropin (HCG)
Pancreatic cancer usually arises from these cells:
islets of Langerhans
pancreatic duct
pancreatic acini
pancreatic duct
Most of the Islets of Langerhans are located in this region:
pancreatic head
around pancreatic ducts
pancreatic tail
pancreatic tail
KUPFFER OR STELLATE
Found in perisinusoidal space
STELLATE
KUPFFER OR STELLATE
produce extracellular matrix (ECM) components
STELLATE
KUPFFER OR STELLATE
recognize and phagocytose aged erythrocytes
KUPFFER
KUPFFER OR STELLATE
also called Ito cells
STELLATE
KUPFFER OR STELLATE
contain lipid droplets that store fat-soluble vitamins
STELLATE
KUPFFER OR STELLATE
remove any bacteria or debris present in the portal blood
KUPFFER
KUPFFER OR STELLATE
become myofibroblasts after liver injury
STELLATE
KUPFFER OR STELLATE
antigen-presenting cells
KUPFFER
KUPFFER OR STELLATE
found within the sinusoidal lining
KUPFFER
Layers in the liver acinus with their functions:
hepatocytes have an intermediate range of metabolic functions
ZONE I
ZONE II
ZONE III
ZONE II
Layers in the liver acinus with their functions:
carry out functions requiring oxidative metabolism
ZONE I
ZONE II
ZONE III
ZONE I
Layers in the liver acinus with their functions:
preferential sites of glycolysis, lipid formation, and drug
biotransformations
ZONE I
ZONE II
ZONE III
ZONE III
Functions of Hepatocytes according to locations:
more involved with detoxification and glycogen
metabolism
A. more central hepatocytes
B. apical surfaces of hepatocytes
C. sinusoidal (basolateral) hepatocytes
D. Hepatocytes near the portal areas
A. more central hepatocytes
Functions of Hepatocytes according to locations:
involved in exocrine secretion of bile
A. more central hepatocytes
B. apical surfaces of hepatocytes
C. sinusoidal (basolateral) hepatocytes
D. Hepatocytes near the portal areas
B. apical surfaces of hepatocytes
Functions of Hepatocytes according to locations:
process blood nutrients and secrete the plasma
proteins
A. more central hepatocytes
B. apical surfaces of hepatocytes
C. sinusoidal (basolateral) hepatocytes
D. Hepatocytes near the portal areas
C. sinusoidal (basolateral) hepatocytes
Functions of Hepatocytes according to locations:
often more active in protein synthesis
A. more central hepatocytes
B. apical surfaces of hepatocytes
C. sinusoidal (basolateral) hepatocytes
D. Hepatocytes near the portal areas
D. Hepatocytes near the portal areas
Characteristics of Adrenal cortex Cells EXCEPT:
tubular mitochondrial cristae
profuse smooth ER (SER)
spherical mitochondria
rich in glycogen droplets
rich in glycogen droplets
This is NOT a part of the adenohypophysis:
pars distalis
pars tuberalis
pars intermedia
pars nervosa
pars nervosa
This is NOT TRUE regarding the blood supply of the liver:
25% comes from the hepatic artery
O2-poor blood from hepatic vein arising from stomach, intestines, and spleen
About 75% of the blood entering the liver is nutrient rich
O2-rich blood comes from hepatic artery
O2-poor blood from hepatic vein arising from stomach, intestines, and spleen
A perisinusoidal space that directly bathe the microvilli projecting from the
hepatocytes:
intercellular space
space of Disse
interlobular space
space of Disse
Abnormalities in Parathyroid Functions:
bones become more mineralized and denser
hyperparathyroidism
hypoparathyroidism
hypoparathyroidism
Abnormalities in Parathyroid Functions:
striated muscles exhibit abnormal contractions
hyperparathyroidism
hypoparathyroidism
hypoparathyroidism
Abnormalities in Parathyroid Functions:
blood calcium deposited pathologically in cartilage,
arteries, or kidneys
hyperparathyroidism
hypoparathyroidism
hyperparathyroidism
This layer occupies 65%-80% of the Adrenal cortex:
zona glomerulosa
zona fasciculata
zona reticularis
zona fasciculata
The initial duct cells in the pancreas extend into lumen of the acinus as small palestaining
centroacinar cells
intercalated cells
cholangiocytes
centroacinar cells
What lines the mucous membrane of the Biliary Tract?
simple columnar epithelium
simple cuboidal epithelium
simple squamous epithelium
simple columnar epithelium
This DOES NOT refer to Diabetes Insipidus:
frequent urination (polyuria) excessive hunger (polyphagia) increased thirst (polydipsia). vasopressin deficiency
excessive hunger (polyphagia)
This is NOT among the physiologic and pharmacologic functions of Melatonin:
A. Anti-oxidant activity
B. Treatment of insomnia among Elderly people
C. Regulation of circadian rhythms axis
D. Treatment of jet lag
E. Increased level of melatonin is needed for the maturation of gonads
E. Increased level of melatonin is needed for the maturation of gonads
To move stored bile into the duodenum, contraction of the gallbladder muscularis is
induced by this substance released from entero endocrine cells of the small
intestine:
cholecystokinin
trypsin
hemosiderin
cholecystokinin
This is UNLIKELY to be a feature of Hepatic sinusoids:
A. converge on the lobule’s central vein
B. arterial blood passes thru sinusoids while portal venous blood into central vein
C. have thin, discontinuous linings of fenestrated endothelial cells
D. emerge from the peripheral branches of the portal vein and hepatic artery
B. arterial blood passes thru sinusoids while portal venous blood into central vein
Composition of the portal triad:
A venule branch of the portal vein
An arteriole branch of the hepatic artery
One or two small bile ductules of cuboidal epithelium
All
All
Describe the correct sequence of the pancreatic ductal system starting from the acini down to the duodenum by assigning letters from A-E
Main pancreatic duct Intercalated ducts Interlobular ducts Centroacinar cells Intralobular ducts
CENTROacinar cells INTERCALATED ducts INTRALOBULAR ducts INTERLOBULAR ducts Main pancreatic duct
Main pancreatic duct-E Intercalated ducts-B Interlobular ducts-D Centroacinar cells-A Intralobular ducts-C
Trace the bile flow starting from its production down to its secretion by assigning letters from A to F
common bile duct bile canaliculi common hepatic duct canals of Hering right & left hepatic ducts bile ductules
bile canaliculi canals of Hering bile ductules right & left hepatic ducts common hepatic duct common bile duct
common bile duct -F bile canaliculi-A common hepatic duct-E canals of Hering-B right & left hepatic ducts-D bile ductules-C
This is a hydrophilic hormone with receptors on the surface of target cells:
peptides
thyroid hormone
steroid
peptides
Diffuse NeuroEndocrine System
induces gall bladder contraction
A. Cholecystokinin /pancreozymin
B. Renin
C. Erythropoietin
D. Vasoactive intestinal polypeptide
A. Cholecystokinin /pancreozymin
Diffuse NeuroEndocrine System
regulation of blood pressure & water balance
A. Cholecystokinin /pancreozymin
B. Renin
C. Erythropoietin
D. Vasoactive intestinal polypeptide
B. Renin
Diffuse NeuroEndocrine System
promotes the formation of red blood cells by the bone marrow
A. Cholecystokinin /pancreozymin
B. Renin
C. Erythropoietin
D. Vasoactive intestinal polypeptide
C. Erythropoietin
The Pineal gland is also called___.
adenohypophysis
neurohypophysis
epiphysis cerebri
Other:
epiphysis cerebri
Cells of the Diffuse NeuroEndocrine System that are stained by solutions of chromium salts are called:
Enterochromaffin cells
argentaffin cells
Chromogranin cells
Enterochromaffin cells
Diabetes Mellitus:
loss of the β cells from autoimmune destruction
TYPE 1
TYPE 2
TYPE 1
Diabetes Mellitus:
insulin-dependent (IDDM)
TYPE 1
TYPE 2
TYPE 1
Diabetes Mellitus:
non–insulin-dependent diabetes mellitus (NIDDM)
TYPE 1
TYPE 2
Type 2 diabetes
Diabetes Mellitus:
juvenile onset
TYPE 1
TYPE 2
TYPE 1
Diabetes Mellitus:
β cells fail to produce adequate insulin
TYPE 1
TYPE 2
TYPE 2
Diabetes Mellitus:
adult onset
TYPE 1
TYPE 2
TYPE 2
The exocrine pancreas secretes approximately ____L of alkaline pancreatic juice per day.
5.1L
1.5L
15L
1.5L
The incomplete obliteration of Rathke’s pouch can lead to remnants that form ____.
cleft cysts
Rathke’s cleft palate
Rathke’s hypophysis
cleft cysts
This statement is INCORRECT regarding calcitonin:
secretion is triggered by low blood Ca2+ levels
it inhibits osteoclast activity
secreted by C cells
secretion is triggered by low blood Ca2+ levels
In this type of secretion, the hormones act on the producing cells themselves or on cells of the same type:
paracrine secretion
juxtacrine secretion
autocrine secretion
autocrine secretion
Short Distance Target Cells
Gastrin made by pyloric G cells
paracrine secretion
autocrine secretion
juxtacrine secretion
paracrine secretion