37&38: GI problem 1 Flashcards
1
Q
Why is nocturnal diarrhoea important?
A
Does not occur in patients with functional disease (IBS)
2
Q
UC involves continuous inflammation starting at the ____
A
Rectum
3
Q
What are the 4 types of presentation of Crohn’s?
A
- Inflammatory
- Stricturing
- Fistulising
- Perianal
4
Q
What is toxic megacolon?
A
- Paralysis of the colon (caused in severe inflammation in UC)
- Causes build up of gas causing dilation
5
Q
How do you treat IBD?
A
- 5-ASA (mild anti inflammatory)
- Steroids (acute flares)
- Immunosuppression (azathioprine) if 5-ASA doesnt work
- Biologics (infliximab, adalimumab)
6
Q
What are the 3 causes of iron deficiency anaemia?
A
- Inadequate dietary intake
- Impaired absorption
- Abnormal loss with occult and overt bleeding
7
Q
What is a mallory-weiss tear?
A
- Tear in lower oesophageal mucosa around the junction
- Typically caused by heavy retching
8
Q
What is an important requirement pre coeliac serology?
A
Needs to be done while consuming gluten
9
Q
What are the antibodies tested for in coeliac?
A
- TGG IgA
- DGP IgG (if IgA low)
10
Q
What are the histological changes seen on duodenal biopsy for coeliac?
A
- Intraepithelial lymphocytosis
- Crypt hyperplasia
- Villous blunting
11
Q
What are the 3 important disease associations with coeliac disease?
A
- Dermatitis herpetiformis
- First degree relative with coeliac
- Type I diabetes
