20 & 21: Vascular Problems 1

Question 1

Which blood test is used to diagnose DVT/PE?

Answer 1

D dimer

Question 2

What are the 3 components of Virchow’s triad?

Answer 2

• Endothelial cell injury
• Hypercoagulability
• Stasis

Question 3

Why might someone with DVT/PE become febrile?

Answer 3

Clot stimulates inflammatory cascade

Question 4

What is the mechanism of enoxiparin?

Answer 4

• Stabilise clot

- Allows endogenous plasmin and protease to break down clot

Question 5

What is the metabolism of dabigatran?

Answer 5

Renal

Question 6

Why might a patient on dabigatran have indigestion?

Answer 6

• Tartaric acid in capsules

- Enhances absorption

Question 7

What are the risk factors for AF?

Answer 7

• Age
• Coronary ischemia
• Hypertension
• Valve disease

Question 8

Treatment for AF is ___ +/- ____

Answer 8

Beta blocker +/- diltiazem

Question 9

What are the two scores that help decide when to use anticoagulation?

Answer 9

• CHADVAS

- HASBLED

Question 10

What is claudication?

Answer 10

Intermittent pain when walking due to muscle ischaemia

Question 11

What is the mechanism of diabetic neuropathy?

Answer 11

Glycosylation of neuronal proteins affects nerve function

Question 12

Why might a patient with diabetes feel faint/sweaty after a meal?

Answer 12

• Autonomic neuropathy

- CNS has an abnormal response