3.4 - Mass transport Flashcards
What are the haemoglobins?
Group of chemically similar molecules found in many different organism
Protein with a quaternary structure
What is the role of haemoglobin and red blood cells in oxygen transport?
To bind to oxygen and carry molecules
Describe the loading, transport and unloading of oxygen by haemoglobin relative to the oxyhaemoglobin dissociation curve
Left - haemoglobin has a higher affinity for oxygen, so associates with oxygen molecules easily, forming oxyhaemoglobin
Right - (Bohr effect) haemoglobin has a lower affinity for oxygen, so dissociates from oxygen molecules more readily
Describe the cooperative nature of oxygen binding to haemoglobin
Haemoglobin molecule undergoes conformational change to tertiary structure after binding of first oxygen, breaking hydrogen bonds, so it becomes easier for the subsequent molecules to bind
Creates another binding site
Describe the effect of carbon dioxide concentration on the dissociation of oxyhaemoglobin
Bohr effect
Decreases pH
Oxygen dissociates from haemoglobin more readily as has a lower affinity for oxygen
Does haemoglobin differ between animals?
Yes, they are adapted to their environment with different types which different transport properties
Draw a labelled diagram of the structure of the heart (including valves) and blood vessels and highlight the flow of blood
Name the blood vessel which supplies oxygen and glucose to the heart muscle
Coronary artery
Describe precautions to take during/after a dissection
Carry sharp instruments pointed away from body
Disinfect instruments and surfaces
Disinfect hands
Dispose of organ in separate bag
Use a sharp scalpel
Wear gloves
Cover any cuts
Explain how an artery can reduce blood flow into capillaries
Muscle contracts
Narrows lumen
Explain how an atrioventricular valve maintains a unidirectional flow of blood
Pressure in atrium is higher than in ventricle so valve opens
Pressure in ventricle is higher than in atrium so valve shuts
Describe the structure and function of arteries
Elastic fibres allow the walls to stretch following ventricular systole, artery maintains high pressure
Smooth endothelial lining which reduces friction of blood flow
Narrow lumen and thick muscular walls to maintain the high pressure so blood can be pushed far distances around the body
Thick smooth muscle layer to exert a high pressure during contraction
Describe the structure and function of arterioles
Same as artery but:
Smaller, thinner muscle wall and elastic layer
Describe the structure and function of veins
Wider lumen than arteries for blood to flow at lower pressures
Thin muscle wall and elastic tissue
Valves to prevent backflow of blood
Describe the structure of capillaries and the importance of capillary beds as exchange surfaces
One cell thick and narrow lumen for short diffusion distance
Highly branched capillary network for large surface area