#32 Flashcards
How does the posterior pituitary glad recieve hormones to secrete?
cells in the hypothalamus make the hormones and it travels down a neuron until it reaches a capilary bed on the posterior pituitary. The axon terminals release the hormones into the capillaries of the posterior pituitary
Effect of dehydration on urine volume
dehydration stimulates osmoreceptors in hypothalamus
ADH/ Vasopressin released from PP
Increased water reabsorption from urine
Vasopressin also causes vasoconstriction
Vasopressin (ADH)
inhibited by activation of stretch receptors in the atria by increased blood volume
stimulated by osmoreceptors in hypothalamus by high blood osmolarity
Oxytocin
released when: mechanoreceptors at areola/cervix are stimulated, infant crying
inhibited by: stress
Oxytocin control of release and actions
Actions: stimulates contractions of the uterus during childbirth. Stimulates contractions of the alveoli and ducts of the mammary glands (milk ejection)
anterior pituitary how do hormones enter the bloodstream
endocrine cells are adjacent to capillary beds, hormones diffuse in
Hormones of the anterior pituitary
FLAT PEG
What does each one do and target?
Growth hormone
synthesized by somatotroph cells of AP
inhibited by somatostatin
stimulated by GHRH
action: stimulate growht and maintainance of body tissues
Stimulates IGF release from liver which acts on epiphesyal plates
increases amino acid uptake into cells and protein synthesis
How does GH promote growth?
GH acts on the liver, increases protein synthesis and cell growth. Liver produces IGF-1, which acts on epiphyseal plates and tell them to extend the bones
Gh and glucose
increases gluconeogenisis, causes insulin resistance, decreased glucose uptake by muscle and fat. Stimulates lipolysis in adipocytes
levels increase during fasting!
hyposecretion of GH
dwarfism (small weak muscle, increased fat)
hypersecretion of GH prior to closure of growth plates
gigantism
hypersecretion of GH after closure of growth plates
acromegaly
does growth hormone aid skeletal muscle anabolism?
no, but it does burn fat!
what connects the hypothalamus and the pituitary gland?
infundibulum