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1 STEP UWorld pathology > 3 chapter (neoplasia) pathoma + FA table ONCOGENES 12/02 > Flashcards

3 chapter (neoplasia) pathoma + FA table ONCOGENES 12/02 Flashcards

1
Q

What is growth factor?

A

PDGFB

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2
Q

PDGFB is what type oncogene?

A

Growth factor

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3
Q

PDGFB function?

A

Platelet-derived growth factor

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4
Q

Mechanism of PDGFB?

A

overexpression, autocrine loop

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5
Q

PDGFB assoc. tumor?

A

Astrocytoma

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6
Q

What are growth factor receptors?

A

ERBB2 [HER2/neu]
RET
KIT

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7
Q

ERBB2 [HER2/neu] is what oncogene?

A

growth factor receptors

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8
Q

RET is what oncogene?

A

growth factor receptors

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9
Q

KIT is what oncogene?

A

growth factor receptors

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10
Q

ERBB2 [HER2/neu] function?

A

Epidermal growth factor receptor

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11
Q

ERBB2 [HER2/neu] mechanism?

A

Amplification

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12
Q

ERBB2 [HER2/neu] assoc. tumor?

A

Subset of breast carcinomas, ovarian carcinoma

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13
Q

RET function?

A

Neural growth factor receptor

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14
Q

RET mechanism?

A

Point mutation

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15
Q

RET assoc. tumor?

A

MEN 2A, MEN 2B and sporadic medullary carcinoma of thyroid, pheochromocytoma

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16
Q

KIT function?

A

Stem cell growth factor receptor

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17
Q

KIT mechanism?

A

Point mutation

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18
Q

What are signal transducers?

A

RAS gene family
ABL

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19
Q

What oncogene is RAS gene family?

A

signal transducer

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20
Q

What oncogene is ABL?

A

Signal transducer

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21
Q

RAS function?

A

GTP-binding protein

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22
Q

RAS mechanism?

A

Point mutation

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23
Q

RAS assoc. tumor?

A

Carcinomas, melanoma and lymphoma

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24
Q

ABL function?

A

non-Tyrosine kinase

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25
Q

ABL mechanism?

A

t (9;22) with BCR;
non-receptor tyrosine kinase

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26
Q

ABL assoc. tumor?

A

CML and some types of ALL

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27
Q

What are nuclear regulators?

A

c-MYC, N-MYC, L-MYC

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28
Q

c-MYC what oncogene?

A

nuclear regulators

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29
Q

N-MYC what oncogene?

A

nuclear regulators

30
Q

L-MYC what oncogene?

A

nuclear regulators

31
Q

c-MYC function?

A

transcription factor

32
Q

N-MYC function?

A

transcription factor

33
Q

L-MYC function?

A

transcription factor

34
Q

c-MYC mechanism?

A

t(8;14) involving IgH

35
Q

c-MYC assoc. tumor?

A

Burkitt lymphoma

36
Q

N-MYC mechanism?

A

amplification

37
Q

N-MYC assoc. tumor?

A

Neuroblastoma

38
Q

L-MYC mechanism?

A

Amplification

39
Q

L-MYC mechanism?

A

amplification

40
Q

L-MYC assoc. tumor?

A

Lung carcinoma (small cell)

41
Q

What are cell cycle regulators?

A

CCND1 (cyclin D1)
CDK4

42
Q

CCND1 (cyclin D1) what oncogene?

A

cell cycle regulators

43
Q

CDK4 what oncogene?

A

cell cycle regulators

44
Q

CCND1 (cyclin D1) function?

45
Q

CCND1 (cyclin D1) mechanism?

A

t(11;14) involvin IgH

46
Q

CCND1 (cyclin D1) assoc. tumor?

A

mantle cell lymphoma

47
Q

CDK4 function?

A

Cyclin-dependent kinase

48
Q

CDK4 mechanism?

A

amplification

49
Q

CDK4 assoc. tumor?

50
Q

FA. ALK (anaplastic lymphoma kinase) what function?

A

receptor tyrosine kinase

51
Q

FA. ALK assoc. turmor?

A

Lung carcinoma (non-small cell); labrge cell lymphomas

52
Q

FA. EGFR (ERBB1) what function?

A

receptor tyrosine kinase

53
Q

FA. EGFR (ERBB1) what tumor?

A

lung adenocarcinoma

54
Q

FA. JAK 2 function?

A

non-receptor tyrosine kinase

55
Q

FA. JAK 2 assoc. tumor?

A

myeloproliferative neoplasms

56
Q

FA. BCR-ABL function?

A

non-receptor tyrosine kinase

57
Q

FA. BCR-ABL tumors?

58
Q

FA. BRAF function?

A

Serine/threonine kinase

59
Q

FA. BRAF tumors?

A

Melanoma, non-Hodgkin lymphoma, colorectal carcinoma, papillary thyroid carcinoma, hairy cell leukemia

60
Q

FA. c-KIT function?

A

cytokine receptor (CD117)
Pathoma - stem cell growth factor receptor

61
Q

FA. c-KIT tumors?

A

Gastrointestinal stromal tumor (GIST), mastocytosis

62
Q

FA. RAS function?

A

RAS GTPase

63
Q

FA. KRAS tumors?

A

Colorectal, lung, pancreatic cancers

64
Q

FA. BCL-2 function?

A

Antiapoptotic molecule (inhibits apoptosis)

65
Q

FA. BCL-2 tumors?

A

Follicular and diffuse large B-Cell Lymphomas

66
Q

FA. BRAF TUMORS.
….., non-Hodgkin lymphoma, colorectal carcinoma, papillary thyroid carcinoma, hairy cell leukemia

67
Q

FA. BRAF TUMORS.
Melanoma, ……………., colorectal carcinoma, papillary thyroid carcinoma, hairy cell leukemia

A

non-Hodgkin lymphoma

68
Q

FA. BRAF TUMORS.
Melanoma, non-Hodgkin lymphoma, …………………, papillary thyroid carcinoma, hairy cell leukemia

A

colorectal carcinoma

69
Q

FA. BRAF TUMORS.
Melanoma, non-Hodgkin lymphoma, colorectal carcinoma, …………………, hairy cell leukemia

A

papillary thyroid carcinoma

70
Q

FA. BRAF TUMORS.
Melanoma, non-Hodgkin lymphoma, colorectal carcinoma, papillary thyroid carcinoma, ………………

A

hairy cell leukemia

1 STEP UWorld pathology (10 decks)

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