3 chapter (neoplasia) pathoma + FA table ONCOGENES 12/02

Question 1

What is growth factor?

Answer 1

PDGFB

Question 2

PDGFB is what type oncogene?

Answer 2

Growth factor

Question 3

PDGFB function?

Answer 3

Platelet-derived growth factor

Question 4

Mechanism of PDGFB?

Answer 4

overexpression, autocrine loop

Question 5

PDGFB assoc. tumor?

Answer 5

Astrocytoma

Question 6

What are growth factor receptors?

Answer 6

ERBB2 [HER2/neu]
RET
KIT

Question 7

ERBB2 [HER2/neu] is what oncogene?

Answer 7

growth factor receptors

Question 8

RET is what oncogene?

Answer 8

growth factor receptors

Question 9

KIT is what oncogene?

Answer 9

growth factor receptors

Question 10

ERBB2 [HER2/neu] function?

Answer 10

Epidermal growth factor receptor

Question 11

ERBB2 [HER2/neu] mechanism?

Answer 11

Amplification

Question 12

ERBB2 [HER2/neu] assoc. tumor?

Answer 12

Subset of breast carcinomas, ovarian carcinoma

Question 13

RET function?

Answer 13

Neural growth factor receptor

Question 14

RET mechanism?

Answer 14

Point mutation

Question 15

RET assoc. tumor?

Answer 15

MEN 2A, MEN 2B and sporadic medullary carcinoma of thyroid, pheochromocytoma

Question 16

KIT function?

Answer 16

Stem cell growth factor receptor

Question 17

KIT mechanism?

Answer 17

Point mutation

Question 18

What are signal transducers?

Answer 18

RAS gene family
ABL

Question 19

What oncogene is RAS gene family?

Answer 19

signal transducer

Question 20

What oncogene is ABL?

Answer 20

Signal transducer

Question 21

RAS function?

Answer 21

GTP-binding protein

Question 22

RAS mechanism?

Answer 22

Point mutation

Question 23

RAS assoc. tumor?

Answer 23

Carcinomas, melanoma and lymphoma

Question 24

ABL function?

Answer 24

non-Tyrosine kinase

Question 25

ABL mechanism?

Answer 25

t (9;22) with BCR; non-receptor tyrosine kinase

Question 26

ABL assoc. tumor?

Answer 26

CML and some types of ALL

Question 27

What are nuclear regulators?

Answer 27

c-MYC, N-MYC, L-MYC

Question 28

c-MYC what oncogene?

Answer 28

nuclear regulators

Question 29

N-MYC what oncogene?

Answer 29

nuclear regulators

Question 30

L-MYC what oncogene?

Answer 30

nuclear regulators

Question 31

c-MYC function?

Answer 31

transcription factor

Question 32

N-MYC function?

Answer 32

transcription factor

Question 33

L-MYC function?

Answer 33

transcription factor

Question 34

c-MYC mechanism?

Answer 34

t(8;14) involving IgH

Question 35

c-MYC assoc. tumor?

Answer 35

Burkitt lymphoma

Question 36

N-MYC mechanism?

Answer 36

amplification

Question 37

N-MYC assoc. tumor?

Answer 37

Neuroblastoma

Question 38

L-MYC mechanism?

Answer 38

Amplification

Question 39

L-MYC mechanism?

Answer 39

amplification

Question 40

L-MYC assoc. tumor?

Answer 40

Lung carcinoma (small cell)

Question 41

What are cell cycle regulators?

Answer 41

CCND1 (cyclin D1) CDK4

Question 42

CCND1 (cyclin D1) what oncogene?

Answer 42

cell cycle regulators

Question 43

CDK4 what oncogene?

Answer 43

cell cycle regulators

Question 44

CCND1 (cyclin D1) function?

Answer 44

Cyclin

Question 45

CCND1 (cyclin D1) mechanism?

Answer 45

t(11;14) involvin IgH

Question 46

CCND1 (cyclin D1) assoc. tumor?

Answer 46

mantle cell lymphoma

Question 47

CDK4 function?

Answer 47

Cyclin-dependent kinase

Question 48

CDK4 mechanism?

Answer 48

amplification

Question 49

CDK4 assoc. tumor?

Answer 49

melanoma

Question 50

FA. ALK (anaplastic lymphoma kinase) what function?

Answer 50

receptor tyrosine kinase

Question 51

FA. ALK assoc. turmor?

Answer 51

Lung carcinoma (non-small cell); labrge cell lymphomas

Question 52

FA. EGFR (ERBB1) what function?

Answer 52

receptor tyrosine kinase

Question 53

FA. EGFR (ERBB1) what tumor?

Answer 53

lung adenocarcinoma

Question 54

FA. JAK 2 function?

Answer 54

non-receptor tyrosine kinase

Question 55

FA. JAK 2 assoc. tumor?

Answer 55

myeloproliferative neoplasms

Question 56

FA. BCR-ABL function?

Answer 56

non-receptor tyrosine kinase

Question 57

FA. BCR-ABL tumors?

Answer 57

CML,ALL

Question 58

FA. BRAF function?

Answer 58

Serine/threonine kinase

Question 59

FA. BRAF tumors?

Answer 59

Melanoma, non-Hodgkin lymphoma, colorectal carcinoma, papillary thyroid carcinoma, hairy cell leukemia

Question 60

FA. c-KIT function?

Answer 60

cytokine receptor (CD117) Pathoma - stem cell growth factor receptor

Question 61

FA. c-KIT tumors?

Answer 61

Gastrointestinal stromal tumor (GIST), mastocytosis

Question 62

FA. RAS function?

Answer 62

RAS GTPase

Question 63

FA. KRAS tumors?

Answer 63

Colorectal, lung, pancreatic cancers

Question 64

FA. BCL-2 function?

Answer 64

Antiapoptotic molecule (inhibits apoptosis)

Question 65

FA. BCL-2 tumors?

Answer 65

Follicular and diffuse large B-Cell Lymphomas

Question 66

FA. BRAF TUMORS. ....., non-Hodgkin lymphoma, colorectal carcinoma, papillary thyroid carcinoma, hairy cell leukemia

Answer 66

Melanoma

Question 67

FA. BRAF TUMORS. Melanoma, ................, colorectal carcinoma, papillary thyroid carcinoma, hairy cell leukemia

Answer 67

non-Hodgkin lymphoma

Question 68

FA. BRAF TUMORS. Melanoma, non-Hodgkin lymphoma, ....................., papillary thyroid carcinoma, hairy cell leukemia

Answer 68

colorectal carcinoma

Question 69

FA. BRAF TUMORS. Melanoma, non-Hodgkin lymphoma, colorectal carcinoma, ....................., hairy cell leukemia

Answer 69

papillary thyroid carcinoma

Question 70

FA. BRAF TUMORS. Melanoma, non-Hodgkin lymphoma, colorectal carcinoma, papillary thyroid carcinoma, ..................

Answer 70

hairy cell leukemia