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1 STEP UWorld pathology > FA serum tumor markers > Flashcards

FA serum tumor markers Flashcards

1
Q

Marker. Alkaline phosphatase. Associations?

A

Metastases to bone or liver, Paget disease of bone, seminoma (placental ALP)

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2
Q

Marker. Alkaline phosphatase. notes?

A

Exclude hepatic origin by checking LFT’s and GGT levels

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3
Q

Marker. Alfa-fetoprotein. Associations?

A

Hepatocellular carcinoma, endodermal sinus (yolk sac) tumor, mixed germ cell tumor, ataxia-teleangiectasia, neural tube defects.

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4
Q

Marker. Alfa-fetoprotein. Notes?

A

Normally made by fetus. Transiently elevated in pregnancy. High levels associated with neural tube and abdominal wall defects, low levels associated with down syndrome.

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5
Q

Marker. hCG. Associations?

A

Hydatidiform moles and choriocarcinomas (gestational trophoblastic disease), testicular cancer, mixed germ cells tumor.

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6
Q

Marker. hCG. notes?

A

produced by syncytiotrophoblasts of the placenta

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7
Q

Marker. Ca 15-3/CA 27-29. Associations?

A

Breast cancer

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8
Q

Marker. CA 19-9 Associations?

A

Pancreatic adenocarcinoma

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9
Q

Marker. CA 125. Associations?

A

Epithelial ovarian cancer

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10
Q

Marker. Calcitonin. Associations?

A

Medullary thyroid carcinoma

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11
Q

Marker. CEA. Associations?

A

Major association: colorectal and pancreatic cancers.
Minor associations: gastric, breast, and medullary thyroid carcinomas.

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12
Q

Marker. CEA. notes?

A

Carcinoembryonic antigen. Very nonspecific.

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13
Q

Marker. Chromogranin. Associations?

A

Neuroendocrine tumors

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14
Q

Marker. LDH. Associations?

A

Testicular germ cell tumors, ovarian dysgerminoma, other cancers.

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15
Q

Marker. LDH. notes?

A

Can be used as an indicator of tumor burden

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16
Q

Marker. Neuron-specific enolase. Associations?

A

Neuroendocrine tumors (eg. small cell lung cancer, carcinoid tumor, neuroblastoma)

17
Q

Marker. PSA. Associations?

A

Prostate cancer

18
Q

Marker. PSA. notes?

A

Prostate specific antigen.
Can also be elevated in BPH and prostatitis.
Questionable risk/benefit for screening. Marker for recurrence after treatment.

1 STEP UWorld pathology (10 decks)

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