[2S] UNIT 9.2 Uric Acid Determination Flashcards
One of the NPNs present in the bloodstream
Uric Acid
Organ in trouble when there is elevation of NPNs in the bloodstream
Kidneys
Only NPN that tells that the liver is in trouble if it is elevated in the bloodstream
Ammonia
Toxic byproduct that needs to be converted to urea for detoxification
Ammonia
Other NPNs circulating in the plasma
Not considered as waste product
Amino acids
Other NPNs circulating in the plasma
● Waste products
● Body needs to get rid of
Urea, Uric acid, Creatinine, Ammonia
End product of purine catabolism
Uric Acid
End product of protein catabolism
Urea
T/F: Urea is higher compared to creatinine
T
Precursor of uric acid
Xanthine
Where is uric acid produced?
Liver
Xanthine is acted upon by what enzyme and to be converted to?
○ Acted upon by Xanthine oxidase
○ To be converted to uric acid
It is a waste product
Uric Acid
Main product of the catabolism of exogenous (dietary) and endogenous purine nucleosides (Adenine and Guanine)
Uric Acid
T/F: Most uric acids are reabsorbed and 1% is excreted
T
T/F: Decrease in serum uric acid is common
F; uncommon
T/F: Although uric acid measurement may assess kidney function, uric acid is not as reliable as that of urea and creatinine.
T
HOW IT TRAVELS FROM HEPATOCYTE TO KIDNEYS
1st organ
Liver
HOW IT TRAVELS FROM HEPATOCYTE TO KIDNEYS
■ Cells that make up the lobules
■ It is where uric acid is produced
Hepatocytes
HOW IT TRAVELS FROM HEPATOCYTE TO KIDNEYS
Functional unit of the liver
Lobules
HOW IT TRAVELS FROM HEPATOCYTE TO KIDNEYS
Very vascular organ riched with blood vessels
Liver
HOW IT TRAVELS FROM HEPATOCYTE TO KIDNEYS
In the liver, ______ synthesize the uric acid
Hepatocytes
HOW IT TRAVELS FROM HEPATOCYTE TO KIDNEYS
travels in the bloodstream in order for them to be disposed properly
Hepatocytes
HOW IT TRAVELS FROM HEPATOCYTE TO KIDNEYS
Urinary bladder → urethra (vary in size)
Inner Medulla
HOW IT TRAVELS FROM HEPATOCYTE TO KIDNEYS
This network of blood vessels are connected to the kidneys
Hepatocytes
HOW IT TRAVELS FROM HEPATOCYTE TO KIDNEYS
3rd site
Kidney (Outer Cortex)
HOW IT TRAVELS FROM HEPATOCYTE TO KIDNEYS
Produce uric acid (waste product) → throw it in the _____
blood
HOW IT TRAVELS FROM HEPATOCYTE TO KIDNEYS
Calyxes and Pelvis → Drains in the ureter and urinary bladder
Inner Medulla
HOW IT TRAVELS FROM HEPATOCYTE TO KIDNEYS
Functional unit of kidney
Nephron
HOW IT TRAVELS FROM HEPATOCYTE TO KIDNEYS
T/F: We can live with only 1 nephron and 1 kidney
F; we cannot live with only 1 nephron
HOW IT TRAVELS FROM HEPATOCYTE TO KIDNEYS
Each kidney contains approximately 1 million to ____ nephrons
1.5 million
HOW IT TRAVELS FROM HEPATOCYTE TO KIDNEYS
● Found in medulla
● Contains blood vessel
Nephron
HOW IT TRAVELS FROM HEPATOCYTE TO KIDNEYS
● Part of nephron that acts as a filter
● Tuft of capillaries
Glomerulus
Why is it reabsorbed if it is a waste product?
It uses raw material for the synthesis of purines
If the physician is requesting for uric acid, it means he/she is suspecting that the patient has inflammatory condition in the joints
Gout
Effective Chemotherapy = ↑ uric acid _ plasma
↑
CHEMOTHERAPY
More cells destroyed _ uric acid
↑ (megalo & cancer)
● Men age 30-50 years old are more commonly affected
● Females: menopausal
Gout
● Decrease concentration of uric acid
● The cells that produces uric acid are destroyed
Liver Disease