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MT6325 > 2S [LEC]: Mature Lymphoid Neoplasms & Plasma Cell Neoplasms > Flashcards

2S [LEC]: Mature Lymphoid Neoplasms & Plasma Cell Neoplasms Flashcards

1
Q

Localization of disease in the lymph nodes and spleen

A

Lymphomas

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2
Q

The lymphoma phase of chronic lymphocytic leukemia

A

Small lymphocytic lymphoma (SLL)

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3
Q

Cell type malignancy associated with Chronic lymphocytic leukemia/ Small lymphocytic lymphoma

A

B cells

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4
Q

A condition where most patients are asymptomatic with indolent and slow-growing B-cell neoplasm primarily composed of small B lymphocytes

A

Chronic lymphocytic leukemia/ Small lymphocytic lymphoma

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5
Q

Population predominantly affected by Chronic lymphocytic leukemia/ Small lymphocytic lymphoma

A

65/72 yrs old (median), Male

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6
Q

A 68-year (M) old patient presents absolute lymphocytosis with 7 x 10^9/L circulating B cells persisting for 3 months. His PBS revealed cobblestone or soccer ball small lymphocytes. What could be the possible condition of the patient?

A

Chronic lymphocytic leukemia

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7
Q

Condition exhibiting smudge cells or basket cells

A

Chronic lymphocytic leukemia/ Small lymphocytic lymphoma

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8
Q

Addition of this reagent to blood before smear preparation stabilized CLL cells, decreasing the formation of smudge cells and allows for accurate cell classification

A

Albumin

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9
Q

A 65-year old (M) patient with B cell malignancy underwent immunophenotyping and presents positive CD19 marker, with weak surface immunoglobulin and CD20 marker. He also presented positive CD5 and CD23 result. What could be his condition?

A

Chronic lymphocytic leukemia/ Small lymphocytic lymphoma

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10
Q

What will be the result of immunophenotyping for CALLA and FMC7 in Chronic lymphocytic leukemia/ Small lymphocytic lymphoma patients?

A

Both are negative

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11
Q

The most common cytogenetic abnormality seen in 50-60% of CLL cases, and has a good prognosis

A

Del(13q14), deletion of 13q

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12
Q

A cytogenetic abnormality associated with CLL with the worst prognosis and is present in <10% of the patients

A

Del(17p) and TP53 abnormalities

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13
Q

Cell type malignancy associated with Prolymphocytic leukemia (PLL)

A

T and B cell

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14
Q

In PLL, which lymphocyte affected has a higher incidence of tissue involvement with skin as a common area of infiltration?

A

T cell

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15
Q

Compared to CLL, PLL is an ___ disorder

A

Aggressive

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16
Q

In PLL, which affected lymphocyte is more commonly occurring?

A

B cell (75%)

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17
Q

The median age affected by PLL

A

70 y/o

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18
Q

A 72-year old (W) patient has a PBS that revealed the presence of lymphocytes with irregular contour and a cerebriform appearance. This patient is also positive for both CD4 and CD8, with negative TdT result. What could be the condition of the patient?

A

T-PLL

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19
Q

A 71-year old (M) patient underwent phenotyping and his malignant lymphocyte showed positive CD19 and CD22, as well as strong CD20 and immunoglobulin reaction. The same sample came back negative for CD5 and FMC7. What could be the condition of the patient?

A

B-PLL

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20
Q

If a patient has TP53 mutation, what possible condition does he have?

A

B-PLL

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21
Q

If a patient has TCL1 gene alterations, what possible condition does he have?

A

T-PLL

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22
Q

A rare and indolent B-cell leukemia that will have a positive TRAP (tartrate-resistant acid phosphatase) staining result

A

Hair cell leukemia

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23
Q

Round to ovoid nuclei, lacking nucleoli, and has a relatively abundant cytoplasm with ragged projections that extend circumferentially around the entire cell

A

Hairy cell

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24
Q

Annexin A1 is indicative of what condition?

A

Hair cell leukemia

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25
Q

A patient that presents enlarged spleen and low RBC, WBC, and platelet count underwent immunophenotyping, with positive CD19, CD20, CD22, CD25 FMC7, surface immunoglobulin results; CD5 and CD23 came back negative. What could be the possible condition?

A

Hair cell leukemia

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26
Q

If a patient has BRAD-V600E mutation, what possible condition may be present?

A

Hairy cell leukemia

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27
Q

A condition now classified separately as splenic B-cell lymphoma with prominent nucleoli

A

Hairy cell leukemia variant (HCL-v)

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28
Q

Result of CD25 and Annexin A1 in patients with HCL-v

A

Both are negative

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29
Q

Abundant, pale blue cytoplasm with distinct medium to large azurophilic granules

A

Large granular lymphocytes

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30
Q

A patient presenting positive result for CD3, CD8, and CD57 has which possible condition?

A

T cell Large granular lymphocytic leukemia (LGL)

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31
Q

A patient presenting positive result for CD56 and negative result for CD3, which has a more aggressive prognosis than its T cell counterpart is possible to have which condition?

A

NK cell Large granular lymphocytic leukemia (LGL)

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32
Q

Proliferation of malignant cells in solid lymphatic tissue

A

Lymphoma

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33
Q

Which kind of lymphoma is less common but is more aggressive?

A

T cell lymphoma (compared to B cell lymphoma)

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34
Q

Presence of Reed-Sternberg cells is indicative of which condition?

A

Classical Hodgkin Lymphoma

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35
Q

An abnormal cell that is described as having owl’s eye appearance

A

Reed-Sternberg cells

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36
Q

Which type of lymphoma is more common, causing 2/3 or more than 75% fatalities?

A

Non-Hodgkin lymphoma

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37
Q

One of the first tumor types cured with combination therapy

A

Hodgkin Lymphoma

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38
Q

Presence of “Popcorn” cells is indicative of which condition?

A

Lymphocyte-predominant Hodgkin-Lymphoma

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39
Q

Which CD markers are possible to reveal positive results if the patient has Classical HL?

A

CD30, CD15

40
Q

Expected CD30 and CD15 results in Lymphocyte-predominant Hodgkin-Lymphoma (LPHL)

A

Both are negative

41
Q

Cell origin of Reed-Sternberg cells

42
Q

A disease of young adults, with 50% of the cases expressing epithelial membrane antigen (EMA)

A

Lymphocyte-predominant Hodgkin-Lymphoma (LPHL)

43
Q

Compared to Hodgkin Lymphoma, Non-Hodgkin Lymphoma is of which cell origin?

A

B cell, T cell, NK cell

44
Q

Among the associated cell types, which cell type of Non-Hodgkin Lymphoma is the most affressive?

45
Q

A condition associated with retroviral infection caused by Human T Lymphocytic Virus Type 1 (HTLV-1)

A

Adult T cell Leukemia/ Lymphoma

46
Q

The neoplastic disorder of Adult T cell Leukemia/ Lymphoma arises from which specific T cell?

A

CD4+ T cell

47
Q

An aggressive type of lymphoma is possible seen on a patient. His PBS showed medium to large lymphocyte with coarsely clumped chromatin and deeply basophilic cytoplasm. This is referred to as “flower cell”, and is common to which condition?

A

Adult T cell Leukemia/ Lymphoma

48
Q

The immunophenotyping of a patient reveals positive results for CD3, CD4, and CD25, but is negative for CD7 and CD8. What could be the possible condition?

A

Adult T cell Leukemia/ Lymphoma

49
Q

An aggressive cancer of mature B cell non-Hodgkin lymphoma

A

Burkitt lymphoma/ leukemia

50
Q

Virus associated with Burkitt Lymphoma, commonly found primarily in childhood in equatorial Africa

A

Epstein-Barr Virus

51
Q

Burkitt Lymphoma subtype that presents mostly as an abdominal disease

A

Sporadic BL

52
Q

Burkitt Lymphoma subtype where bone marrow and the CNS are involved

A

Sporadic BL

53
Q

Burkitt Lymphoma subtype that is associated with immunosuppression

A

HIV associated Burkitt Lymphoma

54
Q

Medium to large-sized cell that has finely clumped chromatin, deeply basophilic cytoplasm with distinct vacuoles

A

Burkitt cell

55
Q

Patients with this condition presents a classic “starry sky” appearance in their bone marrow and lymph node biopsies, which results from macrophages suspended in a sea of malignant cells

A

Burkitt Lymphoma

56
Q

A patient with t(8;14) is possible to have which condition?

A

Burkitt Lymphoma

57
Q

A patient with MYC/IgH mutation is possible to have which condition?

A

Burkitt Lymphoma

58
Q

The MYC gene is located on which chromosome?

A

Chromosome 8

59
Q

The Ig heavy chain is located on which chromosome?

A

Chromosome 14

60
Q

A patient with positive CD20, CD19, CD10 and negative CD5 and CD23 with the MYC gene juxtaposed with the DNA sequence of the immunoglobulin gene is possible to have which condition?

A

Burkitt Lymphoma

61
Q

Neoplastic disorder of germinal B cell

A

Follicular lymphoma (FL)

62
Q

Second most common lymphoma

A

Follicular lymphoma (FL)

63
Q

If the patient has a PBS with lymphocytes showing condensed chromatin pattern and distinct nuclear clefts, what is the possible condition of the patient?

A

Follicular lymphoma (FL)

64
Q

Overexpression of this gene results to blockage of apoptosis, causing follicular lymphoma

65
Q

If a patient has genetic mutation t(14;18) it is possible that he has which condition?

A

Follicular lymphoma

66
Q

A clinically aggressive lymphoma that arises from naive pre-germinal B-cells located in the mantle zone of lymphoid follicles

A

Mantle cell lymphoma (MCL)

67
Q

If a patient is positive for Cyclin D1, which condition does the patient possibly have?

A

Mantle cell lymphoma (MCL)

68
Q

A patient presenting t(11;14) abnormality is possible to have which condition?

A

Mantle cell lymphoma (MCL)

69
Q

A patient presenting overexpression of SOX11 is possible to have which condition?

A

Mantle cell lymphoma (MCL)

70
Q

An indolent B cell lymphoma arising from memory B-cells of lymphoid follicles

A

Marginal Zone Lymphoma (MZL)

71
Q

A condition most commonly associated with chronic inflammation or infection caused by H. pylori

A

Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT)

72
Q

A patient with MALT lymphoma associated with resistance to H. pylori presents what cytogenetic abnormality?

73
Q

Most common form of non-Hodgkin Lymphoma

A

Diffuse Large B Cell lymphoma (DLBCL)

74
Q

Highly pleomorphic cell with large nuclei and nucleoli resembling leukemic blasts

A

Large atypical B-cells

75
Q

Large atypical B-cells are present in which condition?

A

Diffuse Large B Cell Lymphoma (DLBCL)

75
Q

Translocation involving the BCL6 gene located at 3q27 possibly presents what condition?

A

Diffuse Large B Cell Lymphoma (DLBCL)

76
Q

Most familiar form of cutaneous T cell lymphoma

A

Mycosis fungoides (MF)

77
Q

Condition that arises from malignant CD4+ T-cells and presents as cutaneous lymphoma, causing skin itching and lesions, leading to ulcerative tumors

A

Mycosis fungoides (MF)

78
Q

Mycosis fungoides (MF) is diagnosed through ___

A

Skin biopsy

79
Q

The leukemic phase of T-cell lymphoma mycosis fungoides

A

Sezary syndrome (SS)

80
Q

The presence of T-cells having cerebriform nucleus appearance described has distinctive folder, groove-like pattern is indicative of which condition?

A

Sezary syndrome (SS)

81
Q

CD7 and CD26 loss is highly specific to which condition?

A

Sezary Syndrome

82
Q

Malignant bone marrow-based plasma cell neoplasm associated with abnormal protein production

A

Plasma cell myeloma

83
Q

Which of the following is presented in multiple myeloma?

i. hypocalcemia
ii. renal dysfunction
iii. anemia
iv. bone lytic lesions

A

ii, iii, iv

*hypercalcemia

84
Q

Rouleaux formation is common on what condition?

A

Multiple Myeloma (MM)
Waldenstrom Macroglobulinemia (MW)

85
Q

Effect of multiple myeloma on ESR rate

86
Q

Plasma cell containing multiple round globules of immunoglobulin

A

Mott cell (morula cell, grape cell)

87
Q

Cell surface markers that are expressed on neoplastic plasma cells and is helpful in the diagnosis of myeloma

A

CD28, CD138

88
Q

B-cell neoplasm characterized by lymphoplasmaproliferative disorder with infiltration of the bone marrow and production of excessive IgM

A

Waldenstrom Macroglobulinemia (MW)

89
Q

Effect of Waldenstrom macroglobulinemia on ESR rate

90
Q

What method of identification is used to distinguish multiple myeloma from Waldenstrom macroglobulinemia

A

Immunoelectrophoresis

91
Q

Gene mutation present in Waldenstrom macroglobulinemia patients

A

Mutation in MYD88 gene

92
Q

A premalignant condition with a low-level monoclonal protein but no organ damage

A

MGUS (monoclonal gammopathy of undetermined significance)

93
Q

A malignant plasma cell disorder that causes bone lesions, anemia, renal failure, and hypercalcemia

A

Multiple Myeloma

94
Q

A B-cell lymphoma with plasmacytic differentiation, producing excess IgM, leading to hyperviscosity syndrome and neuropathy

A

Waldenstrom Macroglobulinemia

95
Q

A blue background is expected in the PBS of patients with what condition?

A

Multiple myeloma

96
Q

Result of CD19 immunophenotyping in plasma cell leukemia

MT6325 (14 decks)

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