1S [LEC]: Introduction to Hematological Neoplasms Flashcards
Identify the hematologic neoplasm:
Originate from bone marrow
Leukemia
Identify the hematologic neoplasm:
Solid tumors originating from lymphatic system
Lymphomas
Identify the hematologic neoplasm:
Immature blood cells in bone marrow do not mature
Myelodysplastic syndrome
The three most common symptoms of acute leukemia
Bleeding (thrombocytopenia)
Fever (Neutropenia)
Fatigue (Anemia)
Identify the etiologic agent:
Adult T cell leukemia/ Lymphoma
HTLV-1 (CD4 invaders)
Identify the etiologic agent:
Burkitt lymphoma
Epstein Barr Virus
Identify the etiologic agent:
Non-Hodgkin Lymphoma
Epstein Barr
HIV-1
Identify the condition based on genetic abnormality:
FA gene mutation
Fanconi’s anemia
Identify the condition based on genetic abnormality:
Mutation in genes for telomerase maintenance
Dyskeratosis congenita
Identify the condition based on genetic abnormality:
TP53 mutation
Li-Fraumeni syndrome
Molecular policeman that promotes cell cycle arrest and apoptosis when damaged DNA cannot be repared
TP53
Identify the condition based on genetic abnormality:
Mutation in ATM
Ataxia telangiectasia
Initiation and maintenance of leukemia
Leukemogenesis
Leukemogenesis is also known as ___
Multihits
Identify the epigenetic mechanism:
Inhibits gene transcription and expression
DNA methylation
Identify the epigenetic mechanism:
Excessive activity closes the DNA activity
Histone acetylation
Identify the epigenetic mechanism:
Inhibits gene expression specifically binding to target mRNA that blocks translation of protein
miRNAs
Overexpression of BCL2 gene due to t(18;14) causes what condition?
Follicular lymphoma
Overexpression of CCND1 due to t(11;14) causes what condition?
Mantle cell lymphoma
