2.9 Plasma Flashcards
What is plasma
Liquid component of blood
Components of blood
Red cells
Plasma
Buddy coat
What does the buffy coat consist of
Leukocytes and platelets
What is serum
Plasma minus the clotting factors
What do serum separator tubes have
Silica coating induces clotting
Layer of gel barrier between cells and serum
How much water in a healthy adult male
40L
Where is water in the body
Intracellular
Interstitial fluid
Blood plasma
Trans cellular fluid
Functions of plasma
Clotting
Immune defence
Osmotic pressure maintenance
Metabolism
Endocrine
Excretion
Two major proteins in plasma
Serum albumin and globulins
Serum albumin
Most abundant protein in plasma
Produced by the liverr
Functions of serum albumin
Transport of lipids hormones and ions
Maintains osmotic pressure
Where is albumin seen in lipolysis
Release fatty acids are transported by albumin for use by tissues in b oxidation
A1AT
Alpha 1 antitrypsin
Where is alpha1antitrypsin produced
Liver
Alpha1antitrypsin function
Inhibits proteases and protects tissues from enzymes
Defective a1at
Compromised lungs where tissue degradation leads to loss of elasticity and respiratory problems e.g. pollutants like smoke and sust
Alpha 2 globulins examples
Haptoglobin and alpha2 macroglobulin
Haptoglobin
Alpha2 globulin
Binds to haemoglobin and the complex is then removed from the spleen
Measuring haptoglobin levels is used in
Diagnosis of haemolytic anaemia
A2 macroglobulin
Protease inhibitor used to inactivate fibrinolysis
Beta globulins examples
Complement proteins c3 and c4
Transferrin
Gamma globulin examples
Immunoglobulins (ANTIBODIES)
CRP
Electrolytes found in plasma
Sodium potassium calcium magnesium
Why do cells become more spherical with a depleted atp
Inward movement of sodium ions and water
What can plasma be used for
Biomarkers for disease
Passive immunotherapy hyper immune globulin
Passive immunity
