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POM 2 G: HAEMATOLOGY > 2.9 Plasma > Flashcards

2.9 Plasma Flashcards

1
Q

What is plasma

A

Liquid component of blood

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2
Q

Components of blood

A

Red cells
Plasma
Buddy coat

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3
Q

What does the buffy coat consist of

A

Leukocytes and platelets

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4
Q

What is serum

A

Plasma minus the clotting factors

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5
Q

What do serum separator tubes have

A

Silica coating induces clotting

Layer of gel barrier between cells and serum

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6
Q

How much water in a healthy adult male

A

40L

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7
Q

Where is water in the body

A

Intracellular

Interstitial fluid

Blood plasma

Trans cellular fluid

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8
Q

Functions of plasma

A

Clotting

Immune defence

Osmotic pressure maintenance

Metabolism

Endocrine

Excretion

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9
Q

Two major proteins in plasma

A

Serum albumin and globulins

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10
Q

Serum albumin

A

Most abundant protein in plasma

Produced by the liverr

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11
Q

Functions of serum albumin

A

Transport of lipids hormones and ions

Maintains osmotic pressure

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12
Q

Where is albumin seen in lipolysis

A

Release fatty acids are transported by albumin for use by tissues in b oxidation

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13
Q

A1AT

A

Alpha 1 antitrypsin

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14
Q

Where is alpha1antitrypsin produced

A

Liver

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15
Q

Alpha1antitrypsin function

A

Inhibits proteases and protects tissues from enzymes

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16
Q

Defective a1at

A

Compromised lungs where tissue degradation leads to loss of elasticity and respiratory problems e.g. pollutants like smoke and sust

17
Q

Alpha 2 globulins examples

A

Haptoglobin and alpha2 macroglobulin

18
Q

Haptoglobin

A

Alpha2 globulin

Binds to haemoglobin and the complex is then removed from the spleen

19
Q

Measuring haptoglobin levels is used in

A

Diagnosis of haemolytic anaemia

20
Q

A2 macroglobulin

A

Protease inhibitor used to inactivate fibrinolysis

21
Q

Beta globulins examples

A

Complement proteins c3 and c4

Transferrin

22
Q

Gamma globulin examples

A

Immunoglobulins (ANTIBODIES)
CRP

23
Q

Electrolytes found in plasma

A

Sodium potassium calcium magnesium

24
Q

Why do cells become more spherical with a depleted atp

A

Inward movement of sodium ions and water

25
Q

What can plasma be used for

A

Biomarkers for disease

Passive immunotherapy hyper immune globulin

Passive immunity

POM 2 G: HAEMATOLOGY (8 decks)

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