29 Bacterial Infections of the LRT 2 Flashcards
bronchopneumonia
atypical pneumonia
bronchi filled with pus, not isolated to one entire lobe
bacterial causes of walking pneumonia
- mycoplasma pneumoniae
- chlamydophila pneumoniae
also (chlamydophil psittaci, coxiella burnettii)
toxic pneumonia
legionella pneumophila
broncopneumonia with gradual onset
- fever, headache, fatigue, muscle ache, dry cough with scant/watery sputum
atypical pneumonia
treatment for atypical pneumonia
tetracycline and erthromycin
no peptidoglycan
mycoplasma
- culture requires supplementation with sterols and nucleotide precursors
- fried egg colony morphology
mycoplasma pneumoniae
mycoplasma virulence factor
P1 adhesin
-binds to base of cilia -> ciliostasis -> epithelial cell damage/death -> defect in mucociliary clearance
- bronchopneumonia with gradual onset
- anemia
- positive cold agglutinin test
mycoplasma pneumoniae
treatment for mycoplasma pneumoniae
tetracycline and macrolide (erthromycin)
NO BETA LACTAMS
treatment for chlamydophila pneumoniae
tetracycline and macrolide
chlamydophil pneumoniae appearance
gram negative obligate intracellular pathogen
causative agent of legionnaire’s disease
legionella pneumophila
causative agent of pontiac fever
legionella pneumophila
characteristics of legionella pneumophila
gram negative
inside cells: coccobacilli
outside cell: pleomorphic
grows in high humidity and on charcoal yeast agar
legionella pneumophila
-mainly exist as parasites of amoeba
outbreaks associated with air conditioning and respiratory therapy devices
legionella pneumophila
virulence and pathogenesis of legionella pneumophila
- target and attach to alveolar macrophages using pili flagella and numerous proteins
- coiling phenomenon upon entry
toxic pneumonia with patchy infiltrates on CXR
- chills , pleurisy, comiting , diarrhea, confusion, delirium
- progressively ill over 3-6 days
- elevated WBC ceount
legionella pneumophila
legionella treatment
NO beta lactams
macrolide of fluroquinolone
