27 Review

Question 1

Which antiviral to treat first presentation of genital herpes simplex?

Answer 1

Aciclovir (7-10 days- unless new lesions appear)

Question 2

CYP2D6 is required to get the active metabolite of which drug?

Answer 2

Codeine

Question 3

What can be safely used to treat gestational hypertension?

Answer 3

Labetalol

Question 4

What is the MOA of warfarin?

Answer 4

Competitively competes with vitamin K for VKOR preventing it being reduced to active form

Question 5

MOA of amiodarone?

Answer 5

Class III anti-arrhythmic (blocks sodium, potassium, calcium channels and as non competitive beta blocker)

Question 6

Why are inhaled particles (of a drug) that are too small ineffective in asthma treatment?

Answer 6

Too small- inhaled and exhaled without getting deposited. Too big- deposited in mouth and oropharynx

Question 7

Are oestrogen well absorbed in the GI tract?

Answer 7

Yes- BUT undergo significant first pass metabolism

Question 8

What is the first line agent for treating status epilepticus?

Answer 8

Benzodiazepines (lorazepam)

Question 9

Can glicazides be used in renally compromised patients?

Answer 9

Yes- metabolised hepatically

Question 10

Treatment for H.pylori eradication?

Answer 10

PPI plus clarithromycin and amoxicillin