26 Neuro Drugs (not including epilepsy) Flashcards

1
Q

What is Parkinson’s? (inc symptoms)

A

Neurodegenerative disorder

Motor symptoms:

Bradykinesia

Tremor (rest/pin rolling)

Rigidity

Shuffling gait

(can affect swallowing and speech)

Non-motor symptoms:

Depression

Cognitive change

Urinary symptoms

Sleep disorder

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are the causes of Parkinson’s?

A

Mostly idiopathic

Other causes:

Drugs

Vascular (small strokes)

Progressice supra nuclear palsy (Tau protein build up)

Neuro imaging can be used to aid diagnosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Outline the pathology of parkinson’s.

A
  • Lewy body deposition
    • Pars compacta of substantia nigra
      • Cause neurodegeneration

Reduced dopamine output

Cortex stimulated less by basal ganglia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What drugs can make myasthenia gravis worse?

A

aminoglycosides

beta blockers

ACE inhibitors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Side effects of pyridostigmine (acetylcholinesterase inhibitor)?

A

SLUDGE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Side effects of typical antipsychotics eg haloperidol or chlorpromazine?

A
  1. Weight gain
  2. Increased prolactin (think dopamine)
  3. Parkinsonism

(Can also be caused by atypical antipsychotics but less )

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Name a modd stabilser and state how it works.

A

Lithium

Compete with magnesium/calcium

Increase serotonin

Enhance effect of other neurotransmitters

How well did you know this?
1
Not at all
2
3
4
5
Perfectly