27. Childhood continence, proteinuria and haematuria & Renal Failure Flashcards

1
Q

Continence:

A
  • Dry in day by 3 yrs – but accidents are common

* Dry at night by 5-6 yrs but much more variable

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2
Q

Incontinence:

A
  • Primary: never have been dry

* Secondary: incontinence after >6 months dry

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3
Q

Enuresis:

A

Disorder of inability to control frequent urination especially at night

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4
Q

Enuresis diagnosis:

A
  • Urine dip stick, urine - test culture and glucose
  • Early morning urine osmolality (To exclude diabetes insipidus, If >300 able to concentrate urine therefore not DI)
  • Renal USS (Anatomy and bladder emptying)
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5
Q

Enuresis – underlying pathology:

A
  • UTI
  • Diabetes
  • Pelvic mass
  • Renal failure
  • Psychological abuse
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6
Q

Management of enuresis:

A
  • Regular toilet, avoid fizzy drinks, avoid bedtime drinks

- Desmopressin for short term use

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7
Q

Causes of proteinuria:

A
  • Nephrotic syndrome
  • Nephritis
  • Renal failure
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8
Q

Test for proteinuria:

A

Dipstick test or 24h urine collection

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9
Q

Nephrotic syndrome:

A

Heavy proteinuria with hypoalbuminaemia and oedema (ascites, pulmonary, peripheral)

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10
Q

Acute complications of nephrotic syndrome:

A
  • Hypovolaemia
  • Infection
  • Thrombosis
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11
Q

Management of nephrotic syndrome:

A
  • High dose steroid 6 week course
  • Steroid sensitive might relapse but long term prognosis
  • If not steroid sensitive -> ESRF
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12
Q

Nephrotic syndrome OR Nephritic syndrome - discern

A

Haematuria

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13
Q

Nephritis – intrinsic kidney disease:

A
  • Post streptococcal
  • Henoch Schoenlein Purpura
  • SLE
  • IgA nephropathy
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14
Q

Nephritis symptoms:

A
  • Haematuria
  • Oedema
  • Hypertension
  • Renal failure
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15
Q

Acute renal failure (3 types)

A
  • Pre-renal: hypovolaemia
  • Renal: haemolytic uraemic syndrome (anaemia, thrombocytopenia, uraemia)
  • Post-renal: obstruction
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16
Q

Chronic renal failure presentation:

A
  • Anorexia
  • Poor growth
  • Hypertension
17
Q

Conditions causing CKD

A
  • Structural abnormalities
  • Nephritis
  • Haemolytic uremic syndrome
18
Q

Renal replacement:

A
  • Done once approaching ESKF + sometimes pre-emptive transplant
  • Peritoneal dialysis
  • Haemodialysis
  • Transplant
19
Q

Peritoneal dialysis:

A

2/3 paediatric dialysis, indwelling peritoneal catheter, overnight cycling for ~12h, continuous ambulatory – small volume continuous fills.

20
Q

Complications of peritoneal dialysis:

A
  • Peritonitis
  • Catheter blockage
  • Tunnel infections
  • Omental blockage
  • Hernia
  • Parental burnout
21
Q

Haemodialysis:

A

1/3 paediatric dialysis, significant disruption to life, challenge of vascular access – indwelling catheter or fistula, haemodialysis at home – for older children with highly motivated family; 4 hours / session 3x / week

22
Q

Haemodialysis complications:

A
  • Haemolysis
  • Air embolism
  • Hypotension
  • Disequilibrium
23
Q

Transplant types:

A
  • Live related donation

- Deceased donor (difficult if significant hypertension)

24
Q

Advantages of transplant:

A
  • Better quality of life

- Reduced mortality and morbidity vs dialysis

25
Q

Complications of transplant:

A
  • Perioperative complications
  • Drug side effect and immunosuppression
  • Acute and chronic rejection
  • Recurrent of renal disease
26
Q

Transplant outcomes

A
  • Living donor: 87% 5 yr survival, 73% 7 year survival, 60% 10 year survival
  • Deceased Donor: 76% 5 yr survival, 60% 7 year survival, 50 % 10 year survival
  • Adolescence and early adulthood show peaks of graft loss