27 - Antiviral drugs and prophylaxis

Question 1

MOA of acyclovir

Answer 1

activated by viral thymidine kinase (TK) to forms that inhibit viral DNA polymerase

Question 2

DOC for HSV 1 and HSV 2

Answer 2

acyclovir

Question 3

Drug that can be used to shorten the duration of lesions in Varicella infection:

Answer 3

acyclovir

Question 4

DOC for CMV infection:

Answer 4

gancyclovir

Question 5

treatment of Hepatitis B:

Answer 5

interferon-alpha and lamivudine

Question 6

• DOC for influenza virus:

- MOA of this drug:

Answer 6

• Oseltamivir

- inhibits neuraminidase, decreasing the release of progeny virus

Question 7

• MOA of lamivudine:

- Drug class:

Answer 7

• inhibits HBV DNA polymerase and HIV reverse transcriptase

- nucleoside reverse transcriptase inhibitor

Question 8

MOA of interferon-alpha:

Answer 8

-degrades viral DNA via activation of host cell RNAse (ribonuclease)

Question 9

• DOC for RSV virus:

- MOA of this drug:

Answer 9

• Ribavirin
• inhibits guanosine triphosphate formation, preventing capping of viral mRNA and thus blocking RNA-dependent RNA polymerase

Question 10

-Monoclonal antibody against RSV:

Answer 10

Pavilizumab

Question 11

Treatment of acute hepatitis C:

Answer 11

interferon-alpha

Question 12

Treatment of chronic hepatitis C:

Answer 12

Ribavirin

Question 13

• MOA of Zidovudine

- Drug class:

Answer 13

• Inhibit HIV reverse transriptase

- nucleoside reverse transcriptase inhibitor

Question 14

MOA of Indinavir

Answer 14

Protease inhibitor, inhibit viral protein processing

Question 15

• MOA of delavirdine

- Drug class:

Answer 15

• inhibit HIV reverse transcriptase without phosphorylation

- non-nucleoside reverse transcriptase inhibitor

Question 16

Identify: an immune response modifier effective for external genital and perianal warts

Answer 16

imiquimod