20 - Prostaglandins and other eicosanoids

Question 1

Eikosanoids are produced from?

Answer 1

Arachidonic acid

Question 2

Cyclooxygenase ____: Found in many tissues and are active in many physiologic processes

Answer 2

1

Question 3

Cyclooxygenase ____: Found primarily in inflammatory cells; major role in tissue injury; synthesis of prostacyclin and prostaglandin

Answer 3

2

Question 4

These constitute the Slow-reacting substances of anaphylaxis

Answer 4

Leukotriene C4, D4

Question 5

Prostaglandin that is protective of gastric mucosa and keeps PDA patent

Answer 5

E1

Question 6

Prostaglandin that increases uterine tone, also maintains PDA

Answer 6

E2

Question 7

Pulmonary prostaglandin

Answer 7

I2

Question 8

Prostaglandin that decreases IOP, increases uterine tone

Answer 8

F2alpha

Question 9

Prostaglandin for Platelet Aggregation

Answer 9

TXA2

Question 10

• Causes increased HCO3 and mucus secretion in the stomach, also causes uterine contraction
• Drug for PUD, prevention of NSAID-induced gastric mucosal injury
• SE: miscarriage, Moebius sequence
• Drug, Class?

Answer 10

Misoprostol, Prostaglandin E1 analog (Gemeprost)

Question 11

• Causes vascular smooth muscle relaxation and vasodilation
• Drug for maintenance of PDA, erectile dysfunction
• SE: priapism, light headedness
• Drug, Class

Answer 11

Alprostadil, Prostaglandin E1 analog

Question 12

• Low concentrations contract, higher concentrations relax uterine and cervical smooth muscle
• Drug for induction of labor, cervical ripening, abortifacient
• SE: cramps, fetal trauma
• Drug, Class

Answer 12

Dinoprostone, Prostaglandin E2 analog (Sulprostone)

Question 13

• Activates FP receptors
• For control of postpartum hemorrhage, abortifacient
• SE: Vomiting, diarrhea, transient bronchoconstriction
• Drug, Class

Answer 13

Carboprost, Prostaglandin F2alpha analog (Bimatoprost, Travoprost, Unioprostone)

Question 14

• Causes vasodilation, reduces platelet aggregation
• Drug for pulmonary HPN, reduces platelet aggregation in dialysis machines
• SE: hypotension, flushing, headache

Answer 14

epoprostenol (prostaglandin I2 analog) (Beraprost, Iloprost, Treprostinil)

Question 15

• Increases outflow of aqueous humor
• Reduces IOP
• Drug for glaucoma
• Alters iris color, causing permanent eye color change

Answer 15

Latanoprost, Prostaglandin F2alpha analog (Bimatoprost, Travoprost, Unoprostone)