26 – Taylorella and Bordetella Flashcards
1
Q
Microbiological characteristics
A
- Small gram-NEGATIVE cocco-bacilli
- Biocontainment level 2
- *Taylorella equigenitalis is notifiable in Canada
2
Q
Microbiological characteristics of Taylorella
A
- Carboxyphilic
- Facultative anaerobe
3
Q
Microbiological characteristics of Bordetella
A
- Obligate aerobes
- Non-fermentable
- *HIGHLY CONTAGIOUS
4
Q
Taylorella natural host or habitat
A
- Host associated
- In equine genital tract
- Do NOT survive well in environment
5
Q
Bordetella natural host or habitat
A
- Respiratory tract of many species
o Healthy and diseased animals - Pigs, dogs, rabbits, people
- *B. bronchiseptica also has an environmental reservoir in amoeba
- Do NOT survive well in environment
6
Q
Virulence factors of Bordetella
A
- Adenylate cyclase haemolysin
- **Dermonecrotic toxin
- Fimbriae
- Tracheal cytotoxin
- Typer III secretion system
- **Pertussis Toxin (B. pertussis)
7
Q
Dermonecrotic toxin of Bordetella
A
- Amount of toxin produced may be related to strain VIRULENCE
- Inhibitory towards porcine osteoblasts (atrophic rhinitis)
- Also required for B. avium to be pathogenic
8
Q
B. pertussis: Pertussis Toxin
A
- *believed to be responsible for WHOOPING COUGH
- Composed of 5, 2-part subunits (A, B)
- Leads to increased cAMP levels
o Affects cells signalling - Has systemic effects: increased insulin
- Inhibits recruitment of WBCs and affects chemokine production
o Interferes with innate response
9
Q
What does T. equigenitalis cause in horses?
A
- Contagious equine metritis
- Venereal disease in horses
o Natural mating or AI - *T. asinigenitalis rarely associated with similar infections
- *NOTIFICABLE DISEASE (CFIA)
10
Q
T. equigenitalis in mares
A
- Vaginal discharge 2-7 days after bredding
- Return to estrous
11
Q
T. equigenitalis in stallions
A
- Doesn’t typically result in clinical disease: SILENT carriers
- Found in smegma accumulating in urethral fossa
12
Q
What is the treatment of T. equigenitalis?
A
- Antimicrobials
- Daily cleansing of vulva and clitoris
o Including clitoral fossa=important site of carriage
13
Q
How can you control T. equigenitalis?
A
- Careful selection of studs
- Screening fo stallions
- Import controls
- *if importing from endemic region=tested and quarantined
14
Q
What does B. avium cause in turkeys?
A
- Turkey Coryza: disease of upper respiratory tract
o Sneezing (called snick)
o Nasal discharge (mucoid, tenacious exudate)
o Altered vocalization
o Mouth breathing
15
Q
B. avium causing Turkey Coryza
A
- highly infectious: up to 100% of flock affected
- affects young birds (<4weeks)
o if see high proportion sneezing=highly suggestive! - 7-10 day incubation
- *low mortality: may be up to 40% if secondary invaders
16
Q
How is B. avium transmitted?
A
- Direct contact
- Contaminated feed, water, litter
- *survives in environment for 1-6 months!
- Can affect chickens=less severe
17
Q
How do you treat B. avium in turkeys?
A
- Antimicrobials (tetracyclines)
18
Q
How do you control B. avium in turkeys?
A
- Vaccinations
- Biosecurity