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Pathology > 2.5 Wound Healing > Flashcards

2.5 Wound Healing Flashcards

Classification I. Regenerative Capacity: A. labile tissues B.. stable tissues C. permanent tissue II. Processes A. Repair 0. Inflammation 1. granulation tissue (type III collagen) 2. scar formation (type I collagen) B. Collagen Synthesis (Lippincott's Illustrated Review) 1. formation of pro-alpha chains (RER) 2. hydroxylation (RER) 3. Glycosylation 4. pro-alpha chains form pre-collagen 5. extracellular cleavage of pro-collagen molecules produce tropocollagen 6. formation

1
Q

regeneration

A

replacement of damaged tissue with native tissue

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2
Q

repair

A

replacement of damaged tissue with scarring (type I collagen)

  1. when regenerative stem cells are lost
  2. in tissues that lack regenerative capacity
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3
Q

classification: labile tissues

A

highly regenerative due to active stem cells

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4
Q

small and large bowel: stem cells

A

mucosal crypts

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5
Q

skin: stem cells

A

basal layer

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6
Q

bone marrow: stem cells

A

hematopoeic cells

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7
Q

CD34

A

marker of hematopoeic stem cells

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8
Q

stem cells of lung

A

type II pneumocytes

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9
Q

classification: stable tissues

A

quiescent, but can reenter cell cycle

ex.
1. liver
2. proximal tubule of kidney

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10
Q

classification: permanent tissue

A

responds to injury with repair instead of regeneration

  1. myocardium
  2. skeletal muscle
  3. neuron
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11
Q

Granulation tissue: fibroblasts

A

deposite type III collagen

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12
Q

Granulation tissue: Capillaries

A

provide nutrients

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13
Q

Granulation tissue: Myofibroblasts

A

contract wound

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14
Q

collagenase

A

a ZINC driven enzyme that removes type III collagen

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15
Q

Type I collagen is found in

A

bONE

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16
Q

Type II collagen is found in

A

carTWOlage

17
Q

Type III collagen is found in

A

pliability

18
Q

Type IV collagen is in

A

basement membrane

19
Q

TGF-a

A

epithelial and fibroblasts growht factor

20
Q

TGF-b

A

important fibroblast growth factor; inhibit inflammation

21
Q

PDGF

A

endothelium, smooth muscle, fibroblast growth factor

22
Q

FGF hint: name doesn’t give everything away

A

ANGIOgenesis, skeletal development

23
Q

VEGF

A

angiogenesis

24
Q

wound healing: primary intention

A

a surgeon brings wound edges brought together

minimal scar formation

25
Q

wound healing: secondary intention

A

edges are not approximated; granulation tissue (Type I) fills in the defect

myofibroblasts contract tissue

26
Q

Vitamin C deficiency

A

delays wound healing

prolyl and lysyl hydroxylase fail to hydroxylate pro-collagen

27
Q

Copper deficiency

A

delays wound healing due to

lysyl oxidase

28
Q

Zinc deficiency

A

delays wound healing due to

collegenase (Type III remains)

29
Q

Dehiscence

A

rupture of a wound

ex. after abdominal surgery

30
Q

hypertrophic scar

A

type I collagen

31
Q

Keloid

A

excess production of scar tissue that is out of proportion to the wound

TYPE III collagen

African Americans
earlobe (face, abdomen)

32
Q

SCAB: pneumonic for collagen

A
  1. skin
  2. connective tissue
  3. arteries
  4. basement membranes

Pathology (9 decks)

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