24

Question 1

Most common site for metastases FROM the lungs?

Answer 1

LUNG METS! Those bitches laugh at babies!!!!!!!!

```
Brain
Liver
Adrenal
Bone
BLAB
~~~

Question 2

Five Guillian Barre assc infections

Answer 2

1. Campylobacter
2. CMV
3. EBV
4. HIV
5. Myco. Pneumonia

Question 3

Dementia with frequent falls, syncope, visual hallucinations

Answer 3

Lewey body

Question 4

Atrophy of caudate?

Answer 4

Huntingtons

Question 5

Degeneration of substantia niagra?

Answer 5

Parkinson’s

Question 6

Dementia with personality changes?

Answer 6

FTD/ Picks

Question 7

Upper + motor neuron signs

Answer 7

ALS

Question 8

CD surface marker on NK cells/ binds IgG

Answer 8

CD16

Question 9

CD surface markers responsible for inhibiting C9 binding/MAC complex?

Answer 9

CD55/59

Question 10

Endotoxin receptor on macs

Answer 10

CD14

Question 11

General survival rate for lung cancers

Answer 11

16% 5 year survival

Question 12

Two classes of lung cancer?
What do they include?
What are three outliers?

Answer 12

Small cell carcinoma, non small cell
Non small cells = adenocarcinoma, squamous cell, large cell
Others: pancoast tumor, carcinoid, mesothelioma

Question 13

Adenocarcinoma

• prevalence
• location in lungs
• important risk factor
• assc mutations

Answer 13

38%; most COMMON!
In peripheral lung
Caused by SMOKING!!

I’m probably not going to memorize this bull crap unless I get snowed in for a month: EGFR, ALK, ROS, RET, KRAS

Question 14

Squamous cell carcinoma: 
Prevalence 
Appearance of lesions 
Association 
Paraneoplastic syndrome

Answer 14

• Central/hilar lesions (Squamous cell is HILARious.) with keratin pearls.
• 2nd most common
• caused by SMOKING
• secretes PTHRP = ^Ca

Question 15

Large cell carcinoma- prognosis and lesion appearance

Answer 15

BIG OL FAT PERIPHERAL ANAPLASTIC NASTY UNDIFFERENTIATED MOTHER EFFER!!!
Very BAD prognosis

Question 16

Small cell carcinoma: 
Lesion appearance 
Risk 
Secretions/ paraneoplastic syndromes 
Prognosis 
Mutations

Answer 16

^^ N:C ratio; Small Cell is Central 
Smoking = risk 
Aggressive 
TP53, MYC,Rb 
PNP syndromes: lambert Eaton, cushings, SiADH

Question 17

What does pancoasts tumor compress?

Answer 17

Cervical chain = Horners

Recurrent laryngeal = hoarseness

Question 18

Carcinoid tumor:
Locations
Prognosis
Assc syndrome

Answer 18

Low grade epi tumor in lungs/ GI 
Causes serotonin syndrome 
Signs = CARCinoid 
C- cutaneous flushing 
A-asthma like wheezing 
R- Rt hear failure 
C-Craps

Question 19

General risks for lung cancer

Answer 19

Radon

Smoking

Question 20

Mesothelioma

• location
• prognosis
• important fact

Answer 20

In pleura.
Half die in first year
NOT ASSC WITH SMOKING!!!!!!!!

Question 21

From what locations do tumors met TO the lungs?

Answer 21

The spots where you pee and poop and stuff.
Colon, breast, prostate, bladder

Maybe because these are areas that make secretions? Like the lungs make secretions?

Question 22

What are the three small cell neoplastic syndrome?

Answer 22

Cushings
SiADH
Lambert Eaton

Question 23

What are the three cancers specifically listed as “caused by smoking”?

Answer 23

Ya think smoking gives you SASs. And you’re right. It does. It gives you Squamous cell, adenocarcinoma, small cell carcinoma.