2.3:11 Effects of disease state on drug absorption

Question 1

What can go wrong with drug absorption?

Answer 1

Changes in gastric and intestinal motility

Changes in SA available for absorption

Altered physical and chemical properties of the intestinal luminal content

Question 2

What are the typical manifestations of crohn’s disease?

Answer 2

Thickening of the intestinal wall, mucosa fissures, fistulas, inflammatory masses, and bengin strictures

Question 3

What are the symptoms of crhon’s disease?

Answer 3

Diarrhoea, abdominal pain, fever and weight loss

Question 4

How does crohns disease effect absorption?

Answer 4

Thickening of the bowel wall and strictures may significantly alter the bowel motility

Mucosal lesions may lead to changes in intestinal permeability

Question 5

What is celicac disease charactorised by?

Answer 5

Atrophy of the small intestinal mucosa that is caused by hypersensitivity to a protein present in wheat: gluten
This impairs absorption of all nutrients including fat

Question 6

What is the result of AIDS?

Answer 6

Diarrhoea and general wasting syndrome frequencyy