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PHGY 1030 EXAM 3 > 22. Allergy and Immunodeficiency Disorders > Flashcards

22. Allergy and Immunodeficiency Disorders Flashcards

1
Q

What is Protective immunity?

A

-Desirable reaction

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2
Q

What is Hypersensitivity?

A

-Undesirable reaction

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3
Q

Why do people hyperreact?

A

-Nature of Antigen
-Type of immune response
-Host genitics

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4
Q

Hypersensitivity Diseases have an _____________ or ___________ immune response to foreign antigens

A

Excessive, aberrant

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5
Q

What are the four types of GEL and Coombs classifications?

A

-Type I-IgE ab
-Type II- ab to tissue anitgens
-Type III immune complexes
-Type IV -cell mediated immunity

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6
Q

What is Type I dependent on?

A

IgE dependent

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7
Q

Cross linking of ___ sitting on their receptors on mast cells by their ____________________ leads to massive release of ___________ and other performed mediators

A

IgE, cognate antigens , Histamines

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8
Q

What is the cause of Type II ?

A

IgM/IgG binding to cell surface molecules results in usual effects: opsonization ,red blood cell agglutination

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9
Q

What are some examples of Type II?

A

-Transfusion reactions
-Hemolytic disease of the new born
-Drug induced hemolytic anemia

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10
Q

What is Type III Hypersensitivity do?

A

-Immune complexes of circulating antigens and IgM or IgG antibiotics deposited in vascular basement membrane.

-Inflammation via complement activation

-They recognize free flowing antigens not the cells

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11
Q

What does Type IV get triggered by?

A

-Poison Ivy
-Cheap jewelry /reactive metals
-Bacteria(TB)
-virus (Hepatitis B)

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12
Q

What is Type IV mediated by?

A

-T cells and their cytokines

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13
Q

What are the two types of Immunodeficiency disorder?

A

-Congenital Immunodeficiency
-Acquired immunodeficiency

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14
Q

What is Congenital immunodeficiency ?

A

-Defects in lymphocyte maturation
-Defect in activation and function
-Defects in innate immunity

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15
Q

What is Acquired immunodeficiency ?

A

-HIV and AIDS
-Malnutrition
-Chemotherapy/irradiation
-Cancer metastasis to bone marrow
-Splenectomy

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16
Q

What is Gene therapy?

A

-Replacement of defective gene in self renewing precursor cells

17
Q

What are the two major aims that Current therapy has?

A

-MInimize and control infections
-Replace defective or absent component by adaptive transfer and/or transplantation

18
Q

What agents are currently being used for replacement therapy?

A

-Pooled gammaglobulins for agammaglobulinemic patients
-Bone marrow transplant for secondary immunoedeficiency

19
Q

What are principles of therapy for secondary immunodeficiency ?

A

-Control oppurtunistic infectioms
-Treat primary cause

20
Q

What is autoimmunity

A

-A failure of an organism to recognize its own constituent parts as self

21
Q

What are the two types of Autoimmune disease ?

A

-Systemic Autoimmunity
-Organ Specific

22
Q

What is Systemic autoimmunity disease?

A

-Autoimmune disease involving several organs and tissues
-Most involve both humoral and cell mediated immunity

23
Q

What is Organ specific disease ?

A

-Immune response directed to specific organs leading to cellular damage and organ destruction

24
Q

What are the factors influencing autoimmune diseases development ?

A

-Environmental : microbes
-Gender : females greater than males
-Others : Injury

25
Q

What happens if you put someone on inflammatory treatment for a long time, is that good?

A

No, because you need your normal immune response against pathogens

26
Q

What are the treatment options of Autoimmune diseases?

A

-Conventional therapies
-New therapies
-Experimental therapies

27
Q

What is conventional therapies ?

A

-Anti inflammatory agents
-Immunosuppressive agents
-Lymphocyte specific Abs

28
Q

What is New therapies?

A

-Blocking TNF receptor
-Depletion of cells to treat systemic lupus erythematosus(SLE)

29
Q

What is Experimental therapies?

A

-Induction of tolerance
-Blocking peptides

PHGY 1030 EXAM 3 (8 decks)

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