17.Gas Exchange and Transport Flashcards

1
Q

What do partial pressure gradients measure?

A

it determines the direction that gas moves in

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2
Q

What is water vapours partial pressure at 37 degrees celsius ?

A

47 mmHg

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3
Q

Remember the Alveolar gas equation

A

go to slide 10 and 11 and practice

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4
Q

Why do we hyperventilate at a higher altitude ?

A

Due to the lack of oxygen

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5
Q

Why do we start feeling more dizzy when we hyperventilate ?

A

Because there is too much CO2 being kicked and barely any O2 going back in

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6
Q

What are two points of gas exchange surface area?

A

-Gas exchange increases with surface area
-Available exchange surface are decreases in diseases

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7
Q

In partial pressure gradient of gases. The steeper this gradient, the __________the rate of ___________.

A

More rapid, Gas transfer

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8
Q

What are two pointers on the thickness of the alveolar capillary interface?

A

-diffusion gradient -opposes gas diffusion
-Worsesns in disease-water,pus,fibrosis.

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9
Q

CO2 is 20x more ____________ than O2

A

diffusible

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10
Q

In the process of gas exchange, the capillary blood has a high partial pressure of _____.

A

O2

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11
Q

Partial pressure for ____ in capillaries is low

A

CO2

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12
Q

O2 diffuses from capillaries into _______________ its partial pressure gradient.

A

Tissue down

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13
Q

Does CO2 diffuse in the same or opposite direction as O2 in gas exchange,

A

opposite

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14
Q

Blood leaving systemic capillaries is low in ___ and high in _____

A

O2,CO2

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15
Q

Blue blood returns to the lungs to acquire ___ and release _____ at the pulmonary alveolar/capillary interface.

A

O2,CO2

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16
Q

In Gas transport, what is O2 bound to ?

A

Hemoglobin

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17
Q

Does Deoxyhemoglobin have oxygen or not ?

A

No oxygen

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18
Q

Does Oxyhemoglobin have oxygen or not?

A

Oxygen bound

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19
Q

Why is it preferred to pick up O2 at the lungs then the tissues?

A

Because the temperature is much lower at the lungs

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20
Q

Is Oxyhemoglbin favorable and is it irreversible or reversible?

A

It is favorable and it is a reversible process

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21
Q

At what point does hemoglobin combine with oxygen?

A

When oxygen diffuses from the alveoli into the pulmonary capillaries

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22
Q

Where does the disassociation of oxyhemoglobin occur?

A

At the tissue cells.

23
Q

Is the disassociation of oxyhemoglobin favoured ?

A

it is favoured becuase as oxygen leaves the systemic capillaries and enters tissue cells

24
Q

Where is the percent Hgb saturation high and the oxygen partial pressure is also high

25
Where is the percent Hgb saturation low and the oxygen partial pressure is also low
Tissue
26
How many molecules of oxygen can each hemoglobin take?
4
27
At the alveolar capillary interface, hemoglobin takes up oxygen continuously until _________________________________________________
hemoglobin is as saturated as possible
28
Why when hemoglobin dumps oxygen into the blood plasma, why is oxygen less favourable to bind?
Because there is lower oxygen tension now.
29
When CO2 is picked top from the tissue cells, what effect does it have on the affinity of hemoglobin for oxygen and what effect does it have on oxygen?
It decreases the affinity of hemoglobin for oxygen and promotes oxygen disassociation from the systemic capillaries and makes oxygen to be less favorable to bind
30
What is the Bohr effect?
When there is more oxygen dissocation and when the hemoglobin curve shifts to the right
31
What is most CO2 transported as?
Bicarbonate
32
How much percent of transported CO2 is bound to Hemoglobin and how much is dissolved in the plasma?
30% is bound and 10% is dissolved
33
The amount of O2 and Co2 dissolved in pulmonary capillary blood is directly proportionally to the ______________ and _______
Alveolar PO2 , PCO2
34
What is Hypoxia and what 4 categories are there?
Its the condition of having insufficient O2 at the cell level. -Hypoxic hypoxia -Anemic hypoxia -Circulatory hypoxia -Histotoxic hypoxia
35
What is Hyperoxia? and when can this happen?
Condition of having an above normal arterial PO2. this can only occur when breathing supplemental O2
36
Hypoxic
-insufficient oxygen supply or uptake -Inadequate hemoglobin saturation
37
Anemic
-Reduced O2 carrying capacity of blood
38
Histotoxic
-Cells cannot use delivered O2
39
What is Hypercapnia and what is it caused by?
It is the condition of having excess CO2 in arterial blood and it is caused by hypoventilation or it could be someone who is sedated
40
What is Hypocapnia and what is is caused by ?
Its below normal arterial PCO2 levels. and it is brought by hyperventilation (anxiety states, fever,aspirin poisoning)
41
What is apnea?
Its when you stop breathing temporarily but it is when you are sleeping and you won't wake up but it affects your body.
42
What is Dyspnea
-Difficult breathing
43
What is Eupnea ?
-Normal
44
What is Hyperpnea?
- "Big" breaths (e.g. exercise)
45
What is Asphyxia?
- No O2 in tissues - carbon monoxide
46
What is suffocation?
-O2 deprivation-airflow cutoff
47
-What is Cyanosis?
-Color due to asphyxia/lack of O2
48
What is respiratory arrest ?
-Stop breathing-permanent
49
What is hypercapnea?
-Too much CO2
50
What is Hyperventilation?
-Too little CO2-due to increased alveolar ventilation
51
What is Hypocapnea?
-Low CO2
52
What is Hypoventilation?
-Too much CO2-due to under-ventilation
53
Circulatory
-Blood ( and thus O2) not reaching tissues