2.1 Molecules to metabolism Flashcards

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1
Q

Organic compounds

A
  • Living organisms contain a vast range of chemical substances, the majority of which are carbon-containing compounds such as glucose, fats and proteins.
  • These are collectively known as organic compounds.
  • However, it is worth noting that there are a few carbon compounds that are not considered to be organic, such as carbon dioxide, carbon monoxide, carbonates and hydrogen carbonates.
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2
Q

Carbon

A
  • Carbon is an element. It has the atomic number 6, which means that it has 4 electrons in its outer shell.
  • These can form four covalent bonds with other carbon atoms or atoms of other elements.
  • This allows a diversity of stable carbon compounds to exist.
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3
Q

Structure of methane

A

Methane consists of a single carbon atom and four hydrogen atoms.

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4
Q

Diagram of carbon atom in a methane molecule

A
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5
Q

Diagram showing carbon chain and ring structures (Carbon is able to react with many other atoms and form stable arrangements)

A
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6
Q

Examples of carbon-based compounds found in living organisms

A
  • lipids
  • carbohydrates
  • nucleic acids
  • proteins.
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7
Q

Carbon can form a diversity of stable compounds due to ___

A

Its ability to form covalent bonds with atoms of carbon or other elements.

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8
Q

Living organisms are made of organic compounds called ___

A

Macromolecules

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9
Q

What are the four types of macromolecules?

A
  • carbohydrates
  • lipids
  • proteins
  • nucleic acids
  • All of them contain carbon, hydrogen and oxygen atoms. Other elements are also present. Nitrogen appears in proteins and nucleic acids, phosphorus in some lipids (phospholipids).
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10
Q

Function of macromolecules

A

They build living cells and take part in numerous biochemical reactions.

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11
Q

What elements are carbohydrates composed of?

A
  • Carbon
  • Hydrogen
  • Oxygen
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12
Q

What is the ratio of hydrogen to oxygen in carbohydrates?

A

2:1

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13
Q

Lipids are a very diverse group of ___

A

Organic compounds.

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13
Q

Examples of lipids

A
  • Steroids (e.g. cholesterol)
  • Waxes
  • Phospholipids
  • Triglyceries
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14
Q

Proteins consist of ___

A

Amino acids that re arranged in long chains.

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15
Q

Nucleic acids are chains just like proteins, but formed by ___

A

Nucleotides

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16
Q

What are macromolecules made up of?

A
  • Smaller monomers

- Monomers join together to form larger structures called polymers

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17
Q

Examples of carbohydrates

A
  • Alpha-D-glucose
  • Beta-D-glucose
  • Starch
  • Ribose
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18
Q

Function of Alpha-D-glucose

A

Used in the production of ATP in cells.

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19
Q

Function of Beta-D-glucose

A

Used to build cell walls in plants.

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20
Q

Function of starch

A

Used as long-term storage in plants.

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21
Q

Function of ribose

A

Used as a component of DNA and RNA.

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22
Q

Examples of lipids

A
  • Triglycerides
  • Steroids
  • Phospholipids
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23
Q

Function of triglycerides

A

Used as long-term storage in adipose tissue in animals.

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24
Q

Function of steroids

A

Used as chemical messengers in the body, have a distinctive ring shape.

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25
Q

Function of phospholipids

A

Major component of plasma membranes.

26
Q

Examples of proteins

A
  • Structural proteins
  • Enzymes
  • Polypeptides
27
Q

Function of structural proteins

A

Proteins such as keratin and collagen form the structural framework of many parts of the body.

28
Q

Function of enzymes

A

Metabolic proteins that speed up chemical reactions in the body.

29
Q

Function of polypeptides

A

A sequence of amino acids that may make up a protein, or a series of polypeptides can also make up a protein.

30
Q

Examples of nucleic acids

A
  • DNA
  • RNA
31
Q

Function of DNA

A

Used to store genetic information.

32
Q

Function of RNA

A

Used to create proteins at ribosomes using the information stored in DNA.

33
Q

Structure of Alpha-D-glucose

A
34
Q

Structure of Beta-D-glucose

A
35
Q

Structure of amino acid

A
36
Q

Diagram showing the structure of fatty acid

A

.

37
Q

Structure of ribose

A
38
Q

How to tell if a monomer is an amino acid or a fatty acid

A

Check the functional groups:

  • Presence of -COOH, also called a carboxyl group and -NH2, also called an amine group, implies the monomer is an amino acid.
  • Presence of -COOH attached to a long hydrocarbon chain implies the monomer is a fatty acid.
39
Q

How to draw a carbohydrate

A
  • When you have to draw a carbohydrate, such as alpha-D-glucose, start by drawing a hexagon with the oxygen atom at the top.
  • Then there should be 5 carbon atoms clockwise, where the last C atom (number 6) is a CH2OH group attached to carbon atom number 5.
  • Then, draw the -OH groups in their correct positions.
  • The difference between alpha and beta-D-glucose is that in beta-D-glucose the hydroxyl group is above the plane of the ring.
  • You may draw a saturated fatty acid simply as CH3(CH2)16COOH. Keep the total number of carbon atoms in the molecule between 8 and 12.
40
Q

How can starch be detected?

A
  • Using iodine solution.

- It turns blue-black in presence of starch in food.

41
Q

How can protein be detected?

A
  • Using a Biuret test

- The liquid in the Biuret turns a purple colour if protein is detected

42
Q

How can some carbohydrates, such a glucose, fructose, and maltose be detected?

A
  • Using Benedict’s solution
  • They are called reducing sugars.
  • Benedict’s solution gradually changes from blue to orange or brick red when heated with a reducing sugar.
43
Q

What type of molecule is this? CH3(CH2)xCOOH

A
  • Fatty acid

- The presence of the functional group -COOH attached to the hydrocarbon chain confirms that it is a fatty acid.

44
Q

Metabolism

A

Metabolism is all of the enzymatic reactions that take place inside a living organism.

45
Q

Anabolism

A
  • Anabolism is the synthesis of complex molecules from simpler molecules; it is a process that requires the input of energy.
  • Anabolism includes the formation of macromolecules from monomers by condensation reactions.
  • For instance, protein and starch are made from amino acids and glucose units, respectively.
46
Q

Catabolism

A
  • Catabolism is the breakdown of complex molecules into simpler molecules and includes the hydrolysis of macromolecules into monomers.
  • The breakdown of sugars (including glycolysis) or fats to release energy are all examples of catabolic reactions.
  • Catabolism is a process during which energy is released.
47
Q

Hydrolysis reaction

A

The breaking of chemical bonds by the addition of water molecules.

48
Q

Condensation reaction

A

The reaction in which two smaller organic molecules combine to form a larger molecule with the accompanied formation of water or some other simple molecule.

49
Q

Define metabolism

A

The sum of all the enzymatic reactions in a cell or organism.

50
Q

Define anabolism

A

The synthesis of more complex molecules from simpler precursor molecules.

51
Q

Define catabolism

A

The breakdown of complex molecules into simpler molecules.

52
Q

Metabolism =

A

Anabolism + catabolism

53
Q

Anabolism =

A

The opposite of catabolism

54
Q

Example of a catabolic reaction

A

Breakdown of glucose during cellular respiration

55
Q

What is urea?

A
  • An organic compound with the formula CO(NH2)2.
  • It is used by the human body to excrete nitrogen because urea is non-toxic and highly soluble.
  • Urea is also widely used as a nitrogen fertilizer.
  • This application of urea has led to its artificial synthesis on a large scale.
56
Q

Artificial synthesis of urea

A
  • Urea was artificially synthesised accidentally by a German chemist named Friedrich Wöhler in 1828.
  • He demonstrated that a by-product of life could be artificially synthesised in a laboratory.
  • Additionally, his experiment was the first one to show that the synthesis of an organic compound from two inorganic molecules was achievable.
  • Hence, he provided evidence that contradicted the theory of vitalism.
57
Q

According to the theory of vitalism, ___

A
  • Organic compounds could only be synthesised by living organisms as they possessed an ‘element’ that non-living things did not have.
  • That element has been referred to as the divine principle or the life spark by some.
  • Thus, the artificial synthesis of urea from inorganic chemicals in the laboratory helped to falsify the theory of vitalism.
58
Q

Diagram of urea

A
59
Q

In 1828, Friedrich Wöhler artificially produced urea (organic compound) by an internal rearrangement of the atoms of ammonium cyanate (inorganic compound). What important principle did this experiment show?

A

That organic compounds can be synthesized without the need for a vital force.

60
Q

How to tell if a compound is organic

A

An organic compound is a compound that contains carbon and is found in living things

Exceptions include carbides (e.g. CaC2), carbonates (CO32–), oxides of carbon (CO, CO2) and cyanides (CN–)

61
Q

What is the theory of vitalism?

A
  • Vitalism was a doctrine that dictated that organic molecules could only be synthesised by living systems
  • It was believed that living things possessed a certain “vital force” needed to make organic molecules
  • Hence organic compounds were thought to possess a non-physical element lacking from inorganic molecules
62
Q

Describe how the theory of vitalism was disproved

A
  • Vitalism as a theory has since been disproven with the discovery that organic molecules can be artificially synthesised
  • In 1828, Frederick Woehler heated an inorganic salt (ammonium cyanate) and produced urea
  • Urea is a waste product of nitrogen metabolism and is eliminated by the kidneys in mammals
  • The artificial synthesis of urea demonstrates that organic molecules are not fundamentally different to inorganic molecules
63
Q

What is the formula of urea?

A

CH₄N₂O