21: Autonomic Pharmacology Flashcards
Major nt of the parasymp system vs symp system
Parasymp: Ach
Symp: NE
Where is NE found?
Vast majority of post-ganglionic symp fibers
Where does Epi synthesis occur?
Adrenal medulla, few epi containing neuronal pathways in brainstem
Where in a neuron is dopamine synthesized?
Cytoplasm
Name some co-transmitters
ATP, neuropeptide Y, VIP, substance P
What enzyme forms ACh?
ChAT
What transports ACh into vesicles?
ATPase-dependent ACh vesicular transporter
Release of ACh into synaptic terminal
AP -> Ca enters cells -> Ca promotes. Fusion of vesicular membrane with cell membrane via SNARE proteins
What happens when ACh binds nAChRs
Binding -> Na entry -> depol and AP in post-ganglionic fiber
Main way ACh signaling is terminated?
ACHe (acetylcholinesterase)
Adrenergic neurotransmission
Neurotransmission of catecholamines (NE, Epi, DA)
End result of a1 receptor activation vs a2
A1: muscle contraction
A2: vascular SM contraction, decreased NE, decreased insulin
B1, B2, and B3 activation results
B1: cardiac increases
B2: SM relaxation
B3: lipolysis in adipose
Which DA receptor is relevant in this material and what does it cause?
D1 in renal SM -> vasodilation, natriuresis, diuresis
General rule for muscarinic receptor stimulation
Stimulates contraction of all SM
