20) Medically Important Gram-Negative Bacilli Flashcards
Medically important gram negative bacilli is a large diverse group of…?
Non spore forming bacteria
Medically important gram negative bacilli have a wide range of habitats such as…?
large intestine( enteric), zoonotic, respiratory, soil, water
Most in gram negative bacilli are not medically important, but some are true pathogens and…?
opportunistic
All medically important gram negative bacilli have outer membrane lipopolysaccharide of the cell wall known as…?
endotoxin
Enodotoxin or lipid A of lipopolysaccharide (LPS) is the primary initiator of
septic shock
Pseudomonas and Burkholderia are what type of pathogens?
opportunistic pathogens
Brucella and Francisella are what type of pathogens?
zoonotic pathogens
Bordetella and Legionella are mainly what type of pathogens?
mainly human pathogens
Pseudomonas aeruginosa is an aerobic, gram negative, nonenteric bacilli with a single polar…?
flagellum
Pseudomonas aeruginosa is free living in…?
Soil, seawater, and freshwater. Also colonize plants and animals.
Pseudomonas aeruginosa are important decomposers and bioremediators used for…?
oil spills and pesticide clean up
Pseudomonas aeruginosa use aerobic respiration and do not ferment…?
carbohydrates
Pseudomonas aeruginosa produce…?
pseudomycins
Pseudomonas aeruginosa is resistant to…?
Soaps, dyes, quaternary ammonium disinfectants, drugs, drying
Pseudomonas aeruginosa produces water soluble pigments that are what color?
blue- green (pyocyanin)
Pseudomonas aeruginosa is a frequent contaminant of…?
Ventilators, IV solutions, anesthesia equipment
Pseudomonas aeruginosa are what type of pathogen?
Opportunistic
How is Pseudomonas aeruginosa acquired?
Nosocomial, soil, water, stain
Pseudomonas aeruginosa nosocomial infections are common to?
Burn patients, pneumonia, cystic fibrosis, UTI’s
Pseudomonas aeruginosa effect healthy individuals in the form of?
Rash, UTI’s, external ear infections from hot tubs/ swimming pools/ sponges/ wash cloths
The odor of Pseudomonas aeruginosa smells…?
grapelike
Is Pseudomonas aeruginosa drug resistant?
Yes multidrug resistant
Treatment for Pseudomonas aeruginosa uses…?
3rd to 5th generation cephalosporins, aminoglycosides, Fluoroquinolones
Burkholderia, Acinetobacter, and Stenotrophomonas are also aerobic gram negative bacilli that have wide variety of habitats in…?
Soil, water, and related environments
Burkholderia, Acinetobacter, and Stenotrophomonas are what type of pathogen?
Opportunistic
Gram negative aerobic brucella has two species which are?
Brucella abortus (cattle), Brucella suis (pigs)
What does brucella and it’s two species cause?
Brucelliosis, Malta fever, undulant fever, and Big Bang disease(zoonosis)
Brucella can be found in…?
Unpasteurized milk or cheese
Brucella can cause wound, digestive tract, respiratory tract or…?
Conjunctiva disease
Symptoms of brucella are…?
flu like symptoms(headache, muscle pain, weakness)
fluctuating pattern of fever- weeks to a year
arthritis, inflammation of liver, spleen, heart, testicles
Brucella has a low mortality rate at what percent?
2%
The treatment for brucella is a combination of doxycycline and rifampin or…?
Streptomycin
Does Brucella have a animal vaccine or human vaccine?
Animal
Burkholderia cepacia is active in biodegradation of a variety of substances and an opportunistic agent in the…?
respiratory tract, urinary tract, and occasionally skin infections drug resistant
Is Burkholderia cepacia drug resistant?
Yes
B. pseudomallei it’s generally acquired from a penetrating injury, wound infections, inhalation from environmental reservoir, bronchitis and pneumonia and septicemia
septicemia
How is Acinetobacter baumanii acquired?
nosocomial and community
Acinetobacter baumanii infects?
wounds, lungs, urinary tract, burns, blood
Is Acinetobacter baumanii drug resistant?
Yes
Stenotrophomonas maltophilia forms…?
biofilms
Stenotrophomonas maltophilia is a contaminant of?
disinfectants dialysis equipment, respiratory equipment, water dispensers, and catheters
Stenotrophomonas maltophilia is a clinical isolate in…?
respiratory soft tissue, blood, and CSF
high resistance to multidrugs
Is Stenotrophomonas maltophilia drug resistant?
yes
Franciscella tularensis causes tularemia which is a zoonotic disease of mammals endemic to the northern hemisphere such as…?
rabbits = rabbit fever
Francisella tularensis is transmitted by contact with infected animals, water and dust, or bites by vectors such as…?
ticks (flies, mosquitoes)
Most common portal of Francisella tularensis is?
skin or eye
Symptoms of Francisella tularensis are…?
ulcerative skin lesions, conjunctival inflammation, sore throat, intestinal disruption, and pulmonary involvement
Francisella tularensis has a 10% death rate in systemic and _______ forms?
pulmonic
Treatment for Francisella tularensis is?
Doxycycline
Does Francisella tularensis have a vaccine?
No
Francisella tularensis has coccobacilli cells that are what color?
blue
Bordatella pertussis causes ________ in babies?
Whooping cough
Bordatella pertussis is acquired by droplets from what kind of individual?
Healthy or infected
Bordatella pertussis has two stages which are?
catarrhal stage and paroxysmal stage
Bordatella pertussis catarrhal stage includes symptoms such as…?
Nasal drainage, congestion, sneezing, and occasional cough
Bordatella pertussis paroxysmal stage includes symptoms such as…?
Recurrent coughing of 10 - 20 coughs that produce a “whoop”
Bordatella pertussis virulence factors include receptors that recognize and bind to ciliated respiratory epithelial cells and toxins that destroy and dislodge what cells?
ciliated cells
With Bordatella pertussis loss of ciliary mechanism leads to…?
buildup of mucus and blockage of the airways
What drug is used to treat Bordatella pertussis?
Erythromycin
Old vaccination for Bordatella pertussis (DPT) contained attenuated pertussis (whole cell) which caused…?
Side effects
New vaccination for Bordatella pertussis (DTaP) contains…?
toxoid (acellular)
Boostrixis a vaccine for Bordatella pertussis for children ages…?
10-18 years
Tetanus vaccine (Td) is given to adolescents/ adults every \_\_\_ years?
10
Vaccine for Bordatella pertussis (Tdap) is given to adolescents/ adults before contact with babies, and ______ women.
Pregnant
DTaP vaccine is given to children in _____ doses to prevent prevent diphtheria, tetanus, and pertussis.
5
Diphtheria and tetanus (DT) vaccine is ONLY given to children that cannot tolerate _______ vaccine
pertussis
Alcaligenes live primarily in soil and water and may become…?
Normal flora
A. faecalis most common alcaligene that is isolated from feces, urine and?
sputum