[2] Abnormalities of Development of the Reproductive Tract

Question 1

Migration of Germ Cells is from?

Answer 1

Yolk Sac to the Genital Ridge

Question 2

DHT Deficient Males presentation at birth

Answer 2

Undescended testes at birth
No prostate
Partially formed vagina
Ambiguous at birth

Question 3

Most common germ cell tumor resulting from failure of proper migration of germ cells from yolk sac to genital ridge

Answer 3

Sacrococcygeal Teratoma

Question 4

Hormones produced by Leydig Cells

Answer 4

Testosterone

5-DHT

Question 5

Hormones produced by Sertoli Cells

Answer 5

Anti-Mullerian Hormone

Question 6

Patient with Androgen Insufficiency Syndrome will present as a male or female?

Answer 6

Female

Question 7

Testes and Ovaries are derived from (3)

Answer 7

1. Mesodermal epithelium
2. Underlying mesenchyme
3. Primordial Germ Cells

Question 8

Only body part with receptors for SRY Antigen

Answer 8

Genital Ridge

Question 9

Responsible for Testis Differentiation

Answer 9

SRY Antigens on the Genital Ridge

Question 10

What differentiates into seminiferous tubules?

Answer 10

Medullary Cords of the Primitive Gonad

Question 11

Origin of Leydig Cells

Answer 11

Interstitial Cells

Question 12

Enzyme that converts Testosterone to 5-DHT

Answer 12

5-Alpha Reductase

Question 13

Testosterone stimulates the Wolffian Duct to form?

Answer 13

Vas Deferens
Seminal Vesicles
Epididymis

Question 14

Primitive gonads normally differentiate into?

Answer 14

Ovaries

Question 15

[Fate in Males and Females]

Genital Tubercle

Answer 15

M: Glans Penis

F: Clitoris

Question 16

[Fate in Males and Females]

Genital Folds

Answer 16

M: Penile Urethra

F: Labia Minora

Question 17

[Fate in Males and Females]

Genital Swellings

Answer 17

M: Scrotal Sacs

F: Labia Majora

Question 18

[Fate in Males and Females]

Urogenital Sinus

Answer 18

M: ?

F: Lower Vagina

Question 19

Mullerian Ducts form?

Answer 19

Fallopian Tube
Uterus
Cervix
Upper Vagina

Question 20

2 Phases of Testes Descent

Answer 20

1. Transabdominal Descent

2. Inguino-scrotal Migration

Question 21

How many months AOG for complete descent of testes?

Answer 21

7 Months

Question 22

Transabdominal Phase is controlled by?

Answer 22

Anti-Mullerian Hormone

Question 23

Inguino-scrotal Migration is dependent by?

Answer 23

Androgen-dependent via Genitofemoral Nerve

Question 24

In Cryptorchidism this testis is usually undescended

Answer 24

Right Testis

Question 25

Adrenal Cortex comes from which germ layer?

Answer 25

Mesoderm

Question 26

Adrenal Medulla comes from which germ layer?

Answer 26

Neural Crest Cells

Question 27

What is used to determine Congenital Adrenal Hyperplasia during newborn screening?

Answer 27

17-hydroxyprogesterone

Question 28

Closed vaginal opening is called?

Answer 28

Labial Synechiae

Question 29

Most common form of gonadal dysgenesis

Answer 29

Turner Syndrome (45XO)

Question 30

What causes True Hermaphroditism

Answer 30

Translocation of SRY Gene on Y Chromosome to a Cryptic Site on the X Chromosome

SOX9 Germ Line Mutations

Question 31

Bipotential gonads consist of a cortex and a medulla, what happens to them in a male?

Answer 31

Cortex Regresses

Medulla Develops

Question 32

Bipotential gonads consist of a cortex and a medulla, what happens to them in a female?

Answer 32

Cortex Develops

Medulla Regresses

Question 33

What level of sex development is determined at Fertilization

Answer 33

Chromosomal/Genetic Sex