1.9 enzyme inhibition

Question 1

what are competitive inhibitors?

Answer 1

substances which bind to the active site of the enzyme

Question 2

what are non- competitive inhibitors?

Answer 2

substances which bond to the allosteric site of the enzyme

Question 3

what happens to the rate of reaction when inhibitors are added?

Answer 3

rate of reaction decreases

Question 4

why do competitive inhibitors decrease the rate of reaction?

Answer 4

binds to the active site of the enzyme instead of the substrate so less enzyme- substrate complexes can take place

Question 5

what happens to the shape of the active site when the competitive inhibitor binds?

Answer 5

nothing

Question 6

can enzymes be reused after a competitive inhibitor has been in its active site?

Answer 6

yes

Question 7

why do non- competitive inhibitors decrease the rate of reaction?

Answer 7

binds to active site and distorts the shape of the active site so less enzyme- substrate complexes can form due to less functional enzymes

Question 8

what happens to the effect of the competitive inhibitor if more substrate is added?

Answer 8

effect of inhibitor decreases

Question 9

what happens to the effect of the non- competitive inhibitor if more substrate is added?

Answer 9

effect of inhibitor remains the same