1.2 Glomerulus Flashcards
where is blood filtered in kidney?
glomerulus
what pushes blood through glomerulus filter?
pressure
renal blood flow RBF
amount of blood flow through glomerulus per minute
approx. 1 L/min
renal plasma flow RPF
amount of plasma flow through kidney per minute
approx. 600 ml/min
how much is normally filtered out of blood?
20%
what substances can leave glomerulus and pass into bowman’s capsule?
how?
-plasma
-electrolytes
-AAs
-glucose
fenestrations
name of fluid in bowman’s capsule
ultrafiltrate
normal GFR
125 ml/min
filtration fraction FF
proportion of fluid reaching kidneys that passes into renal tubules
GFR/RPF
how to calculate RPF
RBF x (1-haematocrit)
normal hot
40-45%
what does glomerular filtrate normally contain, and not?
yes
-organic solutes
-electrloytes
no
-blood cells
-platelets
-protein
adaptation of PCT for its function
brush border to help reabsorption
podocyte foot processes function
-filtration slits
-repel negative charge e.g. albumin
is nephron filtrate considered to be internal in the body?
no
why might kidney function not fall obviously when kidneys decline slowly?
nephrons can hypertrophy to compensate
effect of age on kidney size
-smaller cortex volume so less effective
when is 51 Cr-EDTA used?
-children
-kidney transplant needed
why isn’t 51 Cr-EDTA used much?
-expensive
-faff
