1.2 Glomerulus

Question 1

where is blood filtered in kidney?

Answer 1

glomerulus

Question 2

what pushes blood through glomerulus filter?

Answer 2

pressure

Question 3

renal blood flow RBF

Answer 3

amount of blood flow through glomerulus per minute

approx. 1 L/min

Question 4

renal plasma flow RPF

Answer 4

amount of plasma flow through kidney per minute

approx. 600 ml/min

Question 5

how much is normally filtered out of blood?

Answer 5

20%

Question 6

what substances can leave glomerulus and pass into bowman’s capsule?

how?

Answer 6

-plasma
-electrolytes
-AAs
-glucose

fenestrations

Question 7

name of fluid in bowman’s capsule

Answer 7

ultrafiltrate

Question 8

normal GFR

Answer 8

125 ml/min

Question 9

filtration fraction FF

Answer 9

proportion of fluid reaching kidneys that passes into renal tubules

GFR/RPF

Question 10

how to calculate RPF

Answer 10

RBF x (1-haematocrit)

Question 11

normal hot

Answer 11

40-45%

Question 12

what does glomerular filtrate normally contain, and not?

Answer 12

yes
-organic solutes
-electrloytes

no
-blood cells
-platelets
-protein

Question 13

adaptation of PCT for its function

Answer 13

brush border to help reabsorption

Question 14

podocyte foot processes function

Answer 14

-filtration slits
-repel negative charge e.g. albumin

Question 15

is nephron filtrate considered to be internal in the body?

Answer 15

no

Question 16

why might kidney function not fall obviously when kidneys decline slowly?

Answer 16

nephrons can hypertrophy to compensate

Question 17

effect of age on kidney size

Answer 17

-smaller cortex volume so less effective

Question 18

when is 51 Cr-EDTA used?

Answer 18

-children
-kidney transplant needed

Question 19

why isn’t 51 Cr-EDTA used much?

Answer 19

-expensive
-faff