12. Carbohydrates: Flashcards
Classification of carbohydrates:
digestible- non digestible classification is based on carbohydrates units Glucose 1 MONOSACCHARADIS sucrose 2 OLIGOSACCARIDES starch many POLYSACCHARIDES
Main carbohydrates in food:
glucose, fructose, sucrose, lactose, starch
Metabolism of carbohydrates:
digestion and absorption in the small intestine (glucose, fructose and starch that is break down by pancreatic amylase become monosaccharides)
fragmentation in the large intestine (lacotse, fructose, fermented by gut flora transformed into volatile fatty acids)
Sugar transporters on enterocytes:
Glucose and galactose transported by sodium-glucose transport protein
fructose is absorbed via facilitated transprt GLUT5
all three transported in the bloos by GLUT2
Carbohydrate malabsorption:
- lactose intolerance
- glucose-galactose malabsorption syndrome
- fructose malabsorption
Requirments carbohydrate:
brain needs 120 g glucose/d
pregnant and lactant lady: 175-210
body can produce glucose from protein and fat
Carbohyrate storage:
Glycogen in the liver 100-120g
glycogen in skletal muscle (420 g)
when no more storage, glucose must come from diet or via gluconeogeesis
Regulation of blood glucose concentration:
Pancreas secrete insulin, secrete glucagon
What is diabetes mallitus?
Type 1 diabetes:
autoimmune destruction of pancreatic cells
not enough insulin is secreted
Type 2 diabetes:
Insulin resistence:
cellular insulin receptor not so sensitve
more insulin secretionrequired for same effect
less glucose homeostasis
Elevate insulin level cause:
Hyperinsulinaemia
basal insulin concentration increase with age
associated with obesity and low physical activity
What prevention of type 2 diabetes:
Decrease risk:
dairy products, whole grains, coffee, tea
Increased risk:
fruit juice, red meat, white rice, french fries
Physical activity is very important!!!
Meal blood glucose response:
Test to help compare foods after increase of blood sugar after a meal
Limitation of GI measurments:
amount of available carbohydrates very different in different products
inter-individual variation in glycemic response
Factors influencing postprandial glucose response:
Type of starch
cooking or food processing
interaction with other nutrients
Factor influencing digestibility of starch:
granular size crystalline structures (A,B,C )