111: Obesity Flashcards
1
Q
what does circulating lepin reflect?
A
body fat% ( produced by adipose tissue)
2
Q
most common genetic cause of inherited obesity
A
mutation in MC4R
3
Q
insulin acts on the hypothalamus to release…
A
anorectic peptides (e.g. MSH) = stop feeding
4
Q
what does a high ghrelin level signal?
A
hunger ( released by stomach)
5
Q
how do we know we are full?
A
stomach distension activated vagus nerve and cycling cholecystokinin (CCK) both tell the hypothalamus.
6
Q
how does orlistat work?
A
intestinal lipase inhibitor
7
Q
how does sibutramine work?
A
serotonin and noradrenaline reuptake inhibitor - reduces appetite.
8
Q
what is Prader-willi Syndrome?
A
genetic disorder (after birth hypotonia and developmental delay
