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Renal > 110314 devo > Flashcards

110314 devo Flashcards

1
Q

what develops from intermediate mesoderm?

A

kidney
calyces
pelvis
ureter

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2
Q

what develops from endoderm?

A

epithelial lining of urinary bladder and urethra

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3
Q

where does the smooth muscle and CT in walls of urinary bladder and urethra come from?

A

splanchnic mesoderm

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4
Q

what does the intermediate mesoderm form?

A

nephrogenic cord (later called the urogenital ridge)

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5
Q

mesonephric duct

A

forms within the nephrogenic cord/ridge in the thoracolumbar region of the embryo

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6
Q

mesonephric kidney

A

transient functional structure
formed within the nephrogenic cord in thoracolumbar reigon of embryo

composed of mesonephric duct and mesonephric tubules

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7
Q

mesonephric tubules

A

immature nephrons

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8
Q

what are the two precursors of the metanephric kidney

A

metanephric diverticulum

metanephrogenic mesenchyme

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9
Q

where does the metanephric diverticulum come from?

A

nephrogenic duct

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10
Q

Potters syndrome

A

renal agenesis
severe urinary obstruction
facial compression, growth retardation, limb deformities

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11
Q

oligohydramnios

A

too little amniotic fluid

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12
Q

what is oligohydramnios associated w

A

renal agenesis
polycystic kidney disease
urethral obstruction

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13
Q

what is a key signaling center for nephron induction?

A

ampulla–expanded tips of the metanephric diverticulum

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14
Q

what do signals from ampulla cause?

A

metanephrogenic mesenchyme to aggregate and form an epithelial vesicle

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15
Q

metanephrogenic mesenchyme

A

accumulation of mesenchyme at caudal end of nephrogenic ridge

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16
Q

multicystic dysplastic kidney is unilateral or bilateral usually?

A

unilateral

polycistic kidney dis is bilateral

17
Q

multicystic dysplastic kidney

A

non genetic
multiple cysts of various sizes
non-functioning
pathology-primitive ductules and cartilage, atretic ureter

will usually regress

18
Q

what is there the potential for with multicystic dysplastic kidney?

A

abnormalities of contralateral kidney, such as vesicoureteral reflux

HTN

19
Q

how does the collecting duct, calyces, pelvis, and ureter form?

A

remodeling and differential growth of the branching metanephric diverticulum

20
Q

cloaca is subdivided by

A

urorectal septum

the primary (primitive) UG sinus is located ventrally

21
Q

how does bladder develop?

A

cranial part of the UG sinus forms urinary bladder and urethra (part)

22
Q

in males, how does the vas deferens develop?

A

mesoneprhic ducts open into urethra rather than urinary bladder (the mesonephric duct distal to metanephric diverticulum becomes the vas deferens)

23
Q

urachus

A

remnant of the allantois

normally becomes the median umbilical ligament

24
Q

exstrophy of bladder

A

defect of ventral abd wall
lining of bladder and urethra is open to surface
babies typically healthy
surgery performed shortly after birth

25
Q

ureteral reflux

A

the higher the grade of reflux, the greater the risk for scarring, the more abnormal anatomy is, spontaneous resolution is less likely, surgical intervention may be needed

can lead to recurrent kidney infections

26
Q

caudal part of UG sinus forms what part of the urethra of male?

A

proximal portion of prostatic urethra

27
Q

definitive UG sinus

A

pelvic portion and phallic portion–contribute to the distal prostatic and membranous urethra in males

28
Q

atresia of urethra is associated with

A

urinary obstruction

Prune belly syndrome

29
Q

posterior urethral valves

A

mucosal folds which obstruct the lumen of urethra
common cause of renal failure in boys
occurs in males ONLY

leads to renal dysplasia
small echo-bright kidneys

30
Q

when does metanephric (mature) kidney begin to form?

A

week 5

31
Q

glomeruli are derived from

A

sprouts of intersegmental arteries

Renal (24 decks)

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