110314 devo Flashcards
what develops from intermediate mesoderm?
kidney
calyces
pelvis
ureter
what develops from endoderm?
epithelial lining of urinary bladder and urethra
where does the smooth muscle and CT in walls of urinary bladder and urethra come from?
splanchnic mesoderm
what does the intermediate mesoderm form?
nephrogenic cord (later called the urogenital ridge)
mesonephric duct
forms within the nephrogenic cord/ridge in the thoracolumbar region of the embryo
mesonephric kidney
transient functional structure
formed within the nephrogenic cord in thoracolumbar reigon of embryo
composed of mesonephric duct and mesonephric tubules
mesonephric tubules
immature nephrons
what are the two precursors of the metanephric kidney
metanephric diverticulum
metanephrogenic mesenchyme
where does the metanephric diverticulum come from?
nephrogenic duct
Potters syndrome
renal agenesis
severe urinary obstruction
facial compression, growth retardation, limb deformities
oligohydramnios
too little amniotic fluid
what is oligohydramnios associated w
renal agenesis
polycystic kidney disease
urethral obstruction
what is a key signaling center for nephron induction?
ampulla–expanded tips of the metanephric diverticulum
what do signals from ampulla cause?
metanephrogenic mesenchyme to aggregate and form an epithelial vesicle
metanephrogenic mesenchyme
accumulation of mesenchyme at caudal end of nephrogenic ridge
multicystic dysplastic kidney is unilateral or bilateral usually?
unilateral
polycistic kidney dis is bilateral
multicystic dysplastic kidney
non genetic
multiple cysts of various sizes
non-functioning
pathology-primitive ductules and cartilage, atretic ureter
will usually regress
what is there the potential for with multicystic dysplastic kidney?
abnormalities of contralateral kidney, such as vesicoureteral reflux
HTN
how does the collecting duct, calyces, pelvis, and ureter form?
remodeling and differential growth of the branching metanephric diverticulum
cloaca is subdivided by
urorectal septum
the primary (primitive) UG sinus is located ventrally
how does bladder develop?
cranial part of the UG sinus forms urinary bladder and urethra (part)
in males, how does the vas deferens develop?
mesoneprhic ducts open into urethra rather than urinary bladder (the mesonephric duct distal to metanephric diverticulum becomes the vas deferens)
urachus
remnant of the allantois
normally becomes the median umbilical ligament
exstrophy of bladder
defect of ventral abd wall
lining of bladder and urethra is open to surface
babies typically healthy
surgery performed shortly after birth
ureteral reflux
the higher the grade of reflux, the greater the risk for scarring, the more abnormal anatomy is, spontaneous resolution is less likely, surgical intervention may be needed
can lead to recurrent kidney infections
caudal part of UG sinus forms what part of the urethra of male?
proximal portion of prostatic urethra
definitive UG sinus
pelvic portion and phallic portion–contribute to the distal prostatic and membranous urethra in males
atresia of urethra is associated with
urinary obstruction
Prune belly syndrome
posterior urethral valves
mucosal folds which obstruct the lumen of urethra
common cause of renal failure in boys
occurs in males ONLY
leads to renal dysplasia
small echo-bright kidneys
when does metanephric (mature) kidney begin to form?
week 5
glomeruli are derived from
sprouts of intersegmental arteries
