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First and second year revision hour > 103. Heamatology > Flashcards

103. Heamatology Flashcards

1
Q

What are the two chemo treatments for AML?

A

Cytosine arorubiside

Demo…..

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2
Q

What are the other drugs for AML

A

Tyrosine kinase inhibitors

Biologics

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3
Q

What is the white blood cell disorder called in CML?

A

Hypoleukostasis

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4
Q

What are the tyrosine kinase inhibitors for CML?

A

Imatanib

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5
Q

What if the tyrosine kinase inhibitors doesn’t work?

A

Still cell transplant

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6
Q

What are the tumour markers in ALL

A

CD19, CD34,

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7
Q

What staging do you use for CLL?

A

Binet staging

A-< 3 lymphs
B- > 3 lymphs
C- b symptoms and 3 LYMPHS

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8
Q

Prognostic for CLL treatment?

A

Lymphocytes double time- 6 month or lower is bad
P53
Advanced disease

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9
Q

Indications for CLL treatment?

A

Massive lymphadenopathy
Big lymphocyte doubling time
Progressive splenomegaly

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10
Q

Treatment for CLL?

A

Tyrosine kinase inhibitors- abratanin
Monoclonal antibodies- rutaximab
Cytotoxic chemo- fludarabine

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11
Q

What are the two main types of non Hodgkin’s lymphoma

A

Follicular lymphoma- low grade (less dangerous, chronic)

Diffuse B cell lymphoma- high grade (more dnagerous, easy to treat)

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12
Q

What molecules are released in tumour lysis syndrome?

A

Potassium
Phosphate
Urea

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13
Q

What is Ann Arbor staging system?

A

1- one region of LYMPHS above diaphragm
2- 2 or more lymph region involvement above the diaphragm
3- Lymph involvement above and below diaphragm
4- systemic involvement (outside LYMPHS)

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14
Q

What is “CRAB” in multiple myeloma?

A

C (hypercalcaemia)
R renal failure
A aneamia
B bone disease

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15
Q

What is multiple myeloma?

A

Cancer of the plasma cells that make your antibodies

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16
Q

What is amyloidosis?

A

Deposition of abnormal proteins (crystallised proteins) in the kidneys (and other places)

17
Q

What is the one test you want to do for paraproteins?

A

Serum electrophereries

18
Q

How do you treat myeloma?

A 
Chemo
Radio
Autologous
Bisphpsphates
Surgery 
Steroids
19
Q

What is MGUS?

A

Monoclonal gammapothy pf unknown significance

First and second year revision hour (14 decks)

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