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Question 1

what is the disadvantage of friedel crafts alkylation

Answer 1

polyalkylation and rearrangement

Question 2

what is the solution to rearrangement in F-C Alkylation

Answer 2

clemmenson reduction reduces a carbonyl to a alkane with Zn/Hg, HCl

Question 3

in the clemmenson reduction, which carbon is being reduced

Answer 3

the benzyilic position

Question 4

what if our molecule is sensitive to acid? what can we reduce a f-c acylation with

Answer 4

the wolf kishner reduction with hydrazine (N2H4, KOH and heat)

Question 5

whats the difference between the clemmenson reduction and the wolf kishner

Answer 5

clemmenson occurs under acidic conditions, wolf kishner occurs under basic conditions

Question 6

whats the reactive intermediate formed in a friedel crafts alkylation

Answer 6

carbocation

Question 7

what source of carbocation is needed for an alkylation

Answer 7

any source of carbocation works

Question 8

what are other sources of carbocations

Answer 8

protonation of an alkene with an acid, acid base reactions

Question 9

why does BF3 act as a lewis acid

Answer 9

it is e poor because it has an empty p orbital (sp2) that can be filled

Question 10

when reacting with an ortho para activator, what products are formed

Answer 10

both products are formed DRAW BOTH

Question 11

what are the reactions of aldehydes and ketones

Answer 11

nucleophilic addition

Question 12

what are the reactions of carboxylic acid derivatives

Answer 12

nucleophilic substitution

Question 13

what are aldehydes called when they are substituents

Answer 13

they are called formyl groups

Question 14

what is a two carbon carbonyl substituent called

Answer 14

a acetyl group

Question 15

how do you get an aldehyde from a primary alcohol

Answer 15

PCC or swern

Question 16

how do you get a ketone from a secondary alcohol

Answer 16

PCC or swern

Question 17

what does ozonoloysis do (O3, Me2S)

Answer 17

cleaves an alkene to make ketones and aldehydes

Question 18

why is DIBAL-H favorable to get a aldehyde in comparison to LAH

Answer 18

it is a weaker reducing agent and will not reduce all the way

Question 19

why is DIBAL-H weaker

Answer 19

it is sterically hindered and less reactive

Question 20

where can the nucleophile attack on a carbonyl in nucleophilic addition? what will it form

Answer 20

it can attack above and below the plane because it is sp2 trigonal planar. If the molecule is chiral it will form a racemic mixture