10 Flashcards
Are secreted from the glands of the endocrine system, they are specific in that each hormone causes a response in a specific target organ or group of cells, rather than on the body as a whole.
HORMONES
are secreted via a duct into the
blood and usually effect a distant organ or tissue.
EXOCRINE HORMONES
are secreted within the tissue
(rather than via a duct) and enter the blood stream via capillaries.
ENDOCRINE HORMONES
Endocrine hormones are secreted within the tissue (rather than via a duct) and enter the blood stream via ______.
CAPILLARIES
6 classes of hormones
• STEROID
• AMINE
• PEPTIDE
• PROTEIN
• GLYCOPROTEIN
• EICOSANOID
Derived from cholesterol which belong to a chemical compounds known as steroids.
STEROID HORMONES
Steroid hormones are derived from cholesterol which belong to a
chemical compounds known as _____.
STEROIDS
Examples of Steroid Hormones
• SEX HORMONES
• ADRENAL CORTEX HORMONES
derived from the modification of amino acids are referred to as amine hormones. Typically, the original structure of the amino acid is modified such that a
COOH, or carboxyl, group is removed, whereas the NH3 + , or amine group remains.
AMINE HORMONES
are synthesized from the amino acids
tryptophan or tyrosine.
AMINE HORMONES
An example of a hormone derived from tryptophan is _____, while tyrosine derivatives include thyroid
hormones and catecholamines.
MELATONIN
These hormones are made up of only few amino acid residues and they are usually present themselves in a form of linear chains.
PEPTIDE HORMONES
Examples of Peptide Hormones:
• OXYTOCIN
• VASOPRESSIN
These hormones are build up from large number of amino acid residues.
PROTEIN HORMONES
Examples of Protein Hormones
• INSULIN
• GLUCAGON
• SOMATOTROPINS
These are conjugated protein bound to
carbohydrate which include galactose,
mannose, fructose.
GLYCOPROTEIN HORMONES
Glycoprotein hormones are conjugated protein bound to carbohydrate which include ______, _____,______.
GALACTOSE, MANNOSE, FRUCTOSE
Examples of Glycoprotein Hormones
LH - LUTEINIZING HORMONES
FLH - FOLLICLE STIMULATING HORMONES
TSH - THYROID STIMULATING HORMONES
Made up of small fatty acid derivatives with a Variety of arachidonic acid.
EICOSANOID HORMONES
Example of Eicosanoid
PROSTAGLANDINS
are classified according to the organs that synthesize them
STEROID HORMONES
Classifications of Steroid Hormones:
• SEX HORMONES
• ADRENAL CORTEX HORMONES
• PLACENTA HERMONES
These are group of hormone that produced in the testes in males and ovaries in the female.
SEX HORMONES
The male sex hormones are usually referred to as?
ANDROGENS
The principal androgen is known as?
TESTOSTERONE
These hormones are produced primarily by the testes and in discrete amounts by the adrenal cortex.
SEX HORMONES
are primarily responsible for the proper
development and maintenance of male
reproductive function and stimulation of the secondary sex characteristics.
ANDROGENS
Androgens are ____, and used in stimulating the production of skeletal muscles and bone as well as red blood cells.
ANABOLIC
Overdosing has been linked to serious side effects, including infertility and coronary heart disease.
SEX HORMONES
two female sex hormones
ESTROGENS and PROGESTINS
are secreted mainly by the ovaries and in smaller amounts by the adrenal glands and (in men) by the testes.
ESTOGENS
The most potent estrogen is?
ESTRADIOL
This hormone has a similar function similarly to androgens in men
ESTROGEN
promote the development and maintenance of the primary and secondary female sexual characteristics; they also stimulate linear growth and skeletal maturation.
ESTOGENS
the most important of which is Progesterone, are the other type of female sex hormone and are named for their role in maintaining pregnancy (pro-gestation).
PROGESTINS
are secreted cyclically during
menstruation.
ESTROGEN and PROGESTINES
They are mainly adrenocortical hormones, which basically divided to two:
GLUCOCORTICOIDS
MINERALOCORTICOIDS
They are mainly adrenocortical hormones, which basically divided to two:
GLUCOCORTICOIDS
MINERALOCORTICOIDS
consist of hormones such as cortisol which mainly control and influence many metabolic processes like deposition
of glycogen in the liver and the formation of glucose from amino acids and fatty acids.
GLUCOCORTICOIDS
consist of hormones such as ____ which mainly control and influence many metabolic processes like deposition
of glycogen in the liver and the formation of glucose from amino
acids and fatty acids
CORTISOL
It also helps in the maintenance of normal blood pressure, and also possessed anti-inflammatory and
immunosuppressive actions, which are useful in treating rheumatoid arthritis and prevents the rejection of transplanted
organs.
GLUCOCORTICOIDS
like aldosterone help maintain the balance
between salts and water in the body and the predominantly exerts their effects within the kidney.
MINERALOCORTICOIDS
is an endocrine gland that is only
present during pregnancy.
PLACENTA
The placenta produces two steroid hormones:
ESTROGEN and PROGESTERONE
The placenta also releases several protein hormones:
• HUMAN CHORIONIC GONADOTROPHIN (hCG)
• HUMAN PLACENTAL LACTOGEN (hPL)
• PLACENTAL GROWTH HORMONE
• RELAXIN
• KISSPEPTIN
These are group of lipophilic hormones that are usually derived from cholesterol (except T3 and T4).
GROUP 1 HORMONES
These hormones usually bind to intracellular receptors thereby forming hormone-receptor complex.
GROUP 1 HORMONES
They are mostly found in general circulation in association with transport proteins however they have relatively longer half-lives in hours or days.
GROUP 1 HORMONES
Examples of Group 1 Hormones:
T3, T4, ESTROGEN, PROGESTERONE, and TESTOSTERONE
These are hormones that bind to cell surface (plasma membrane) receptor before they stimulate the release of
certain molecules known as second messenger which will then perform the biochemical function of these hormones.
GROUP 2 HORMONES
These are hormones that bind to cell surface (plasma membrane) receptor before they stimulate the release of
certain molecules known as _____ which will then perform the biochemical function of these hormones.
SECOND MESSENGER
These hormones have a specific local effect through paracrine secretion.
LOCAL HORMONES
Examples of local hormones
HORMONE TESTOSTERONE
These are hormones transported through circulation to the distal target tissue/organ.
GENERAL HORMONES
Examples of general hormones
THYROID HORMONES and INSULIN
These hormones may cause muscle contraction, pigment migration, glandular secretion and others.
KINETIC HORMONES
Example of kinetic hormones
EPINEPHRINE
These are hormones that mainly caused changes in the rate of metabolism and balance the reaction.
METABOLIC HORMONES
Examples of Metabolic Hormones
• INSULIN
• GLUCAGON
• PARATHYROID HORMONES
Nature of Action of Hormones
LOCAL HORMOES
GENERAL HORMONES
These are hormones that mainly involved in growth and differentiation in the body.
MORPHOGENETIC HORMONES
Examples of Morphogenetic Hormones
FOLLICLE STIMULATING HORMONES
LUTEINIZING HORMONES
THYROID HORMONES
Amine hormones are synthesized from the amino acids _____ or _____.
TRYPTOPHAN or TYROSINE
These are group of hormone that produced in the ____ in males and ____ in the female.
TESTES, OVARIES
Overdosing has been linked to serious side effects, including ____ and ____
INFERTILITY and CORONARY HEART DISEASE