1 - Homeostasis & Fluid Balance Flashcards

1
Q

What is the meaning of the word homeostasis?

A

Homeo - the same
Stasis - standing still

The process by which cells, tissues and organisms maintain a state of internal balance

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2
Q

Give some examples of different factors that are maintained under homeostasis?

A
  • Oxygen, carbon dioxide, salts etc.
  • Nutrients and waste products
  • pH, temperature, volume and pressure
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3
Q

What is negative feedback? Give an example.

A

The output from the effector acts to reduce the stimulus back to baseline

E.g. blood glucose levels

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4
Q

When does a negative feedback loop stop?

A

When the effector ceases

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5
Q

What is positive feedback? Give an example.

A

The output of the effector enhances or exaggerates the original stimulus

E.g. regulation of blood clotting, oxytocin release in childbirth

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6
Q

When does a positive feedback loop stop?

A

When the initiator ceases

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7
Q

What is the core body temperature maintained at?

A

36.5 to 37.5 degrees

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8
Q

What feedback mechanisms occur in response to hot temperatures?

A
  • Vasodilation - heat radiates from the skin
  • Sweating - evaporative cooling
  • Pilorelaxation
  • Stretching out
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9
Q

What feedback mechanisms occur in response to cold temperatures?

A
  • Vasoconstriction - diverts blood to the deeper tissues
  • Shivering - generates heat
  • Piloerection - traps air close to the skin
  • Curling up
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10
Q

What can influence the body’s set temperature (the temperature it is maintained at)?

A
  • Pyrogens - released by immune cells in response to infection
  • Exercise training and heat acclimation
  • Biological rhythms
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11
Q

Below what temperature is hypothermia? What are the symptoms?

A
  • Below 36.5 (mild) or below 32 (severe)
  • Mild - shivering, fatigue, confusion
  • Severe - no shivering, rigid muscles, weak pulse
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12
Q

What happens to the body below 28 degrees?

A

Appearance of death (no vital signs) but not dead until warm and dead!

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13
Q

At what temperature is a fever? What are the symptoms?

A
  1. 5 to 40 degrees

- Pale sweaty skin, cramps

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14
Q

At what temperature does heat stroke occur? What are the symptoms?

A

40-46 degrees

- Flushed dry skin, hot to the touch, strong bounding pulse

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15
Q

At what temperature does heat exhaustion occur? What are the symptoms?

A

Above 46 degrees

- Unconsciousness, seizures, confusion, headache, dizziness

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16
Q

What is normal pH in the body?

A

7.35 - 7.45

17
Q

What two organs are responsible for regulating pH?

A

Lungs - respiratory balance

Kidneys - metabolic balance

18
Q

What are the terms used for:

  • high pH?
  • low pH?
A
  • High - alkalosis

- Low - acidosis

19
Q

What is the pH of the stomach acid?

What can happen if the stomach acid enters the oesophagus? What happens if the stomach loses its protection?

A

1.5 to 3.5

  • Oesophagus - oesophagitis
  • Stomach - ulceration and perforation
20
Q

What buffering systems exist in the body?

A
  • Carbonic acid - bicarbonate (blood)

- Sodium phosphate buffering

21
Q

What is the composition of water in the ICF and ECF?

Within the ECF how is the fluid distributed?

A

2/3 ICF
1/3 ECF

Within the ECF:

  • 80% interstitial fluid
  • 20% plasma
22
Q

What is the total volume of blood?

A

5 litres

23
Q

What is hypertonicity?

A

When there is less water inside the cell (more water outside) - cell shrinks

24
Q

What is hypotonicity?

A

When there is more water inside the cell (less water outside) - cell swells

25
Q

Bulk water flow can occur through ………..

A

aquaporins

26
Q

What is osmolality? What is the normal range?

How does it differ from osmolarity?

A

Number of solute particles per kilogram. 280 - 300 mOsm/kg

Does not depend on temperature and pressure

27
Q

What is oedema? Why does this occur?

A
  • Fluid retention, commonly peripheral oedema in the ankles

- Occurs when hydrostatic pressure > osmotic pressure