1 - DOC Flashcards
Hypertriglyceridemia
Fibrates
- gemfibrozil
- fenofibrate
- bezafibrate
- Activates PPAR-a
- increase expression of lipoprotein lipase and apolipoprotei
- lowers TG
- decrease secretion of VLDL
- increase HDL
Acute migraine
5-HT 1D agonist
- sumatriptan
- causes vasoconstruction
- modulates neurotransmitter release
Acute asthma attacks
Albuterol/salbutamol
- B2-selective agonist
- bronchodilation
Triple therapy for COPD-Asthma overlap
LAMA + LABA + inhaled ICS
Asthma prophylaxis
Fluticasone
- corticosteroid
- inhibitor of phospholipase A2
- reduces expression of COX
Status asthmaticus
IV prednisolone or hydrocortisone
Prednisolone - active metabolite of prednisone
Anticoagulation for pregnancy
Heparin
- activates antithrombin III
- indirect anticoagulant
- PTT
- intrinsic
DMARD of first choice for Rheumatoid Arthritis
Methotrexate
1st line for chronic gout
Allopurinol
- xanthine oxidase inhibitor
- alloxanthine - active metabolite that irreversibly inhibits xanthine oxidase
Gonorrhea
Ceftriaxone and Cefixime
Syphilis
Penicillin
- binds to PBP
- inhibits transpeptidation in bacterial cell walls
Toxoplasmosis
Sulfadiazine-Pyrimethamine
- antifolate drug
Pyrimethamine
- co-administered with Leucovorin to limit bone marrow toxicity
DOC for ameobiasis, giardiasis and pseudomembranous colitis
Metronidazole
- nitroimidazole, antiprotozoal
- MOA: reactive reduction of ferredoxin forminh free radicals that disrupt the ETC
Prinzmetal Angina
Diltiazem
- ND CCB
- cardiac > vascular
Ventricular arrhythmias
Lidocaine
- Class 1B anti arrhythmic
MeLT
- Mexiletine
- Lidocaine
- Tocainide
Paroxysmal Supraventricular Tachycardia
Adenosine
Prevent fulminant hepatitis in acetaminophen toxicity
N-acetylcysteine
Diabetic gastroparesis
Metoclopramide
Seizures in infants
Phenobarbital
Delirium tremens
Long-acting BZD
- diazepam
- chlordiazepoxide
Opioid overdose
Naloxone
Opioid dependence and chronic alcoholism
Naltrexone
Absence seizure
- Ethosuximide (DOC)
- Valproic acid
2nd line: clonazepam
Generalized tonic-clonic seizures
- Phenytoin
- Carbamazepine
- Valproic acid
Partial seizures
- Phenytoin
- Carbamazepine
- Lamotrigine
Trigeminal neuralgia
Carbamazepine
Other:
- oxcarbazepine
Bipolar disorder (acute mania)
Valproic acid (first line for mania)
- Carbamazepine
- Lamotrigine
Status epilepticus
- Lorazepam
- Diazepam
- Phenytoin
- Phenobarbital
Malignant Hyperthermia
Dantrolene
