1. Flashcards
What is inflammation?
The response of living tissue to injury.
What do we need to determine about injuries during a post-mortem exam?
Whether the injuries occurred before or after death.
Can inflammation occur after death?
No.
What is the goal of treating inflammation?
We want to get rid of what is causes the inflammation and return the body to homeostasis.
What 4 things cause inflammation?
Pathogenic organisms.
Poisons and toxins.
Mechanical and thermal injuries.
Immune reactions.
What are the 5 cardinal signs of inflammation?
Rubor (redness).
Calor (heat).
Tumor (swelling).
Dolar (pain).
Functio laesa (loss of function).
What causes the redness and heat associated with inflammation?
The dilation of the blood vessels.
What causes the swelling associated with inflammation?
An accumulation of fluid from leaky blood vessels.
What 2 factors lead to the pain associated with inflammation?
Bradykinin.
Prostaglandin.
What causes the loss of function associated with inflamamtion?
The pain and swelling.
What are the 5 main steps in the vascular response following inflammation?
Vasodilation.
Increased vascular permeability.
Change in blood flow.
Leukocyte margination, rolling and adhesion.
Leukocyte emigration.
What are the 2 major factors that lead to vasodilation?
Histamine.
Bradykinin.
What is hyperemia?
Excess blood in the blood vessels.
Why is vasodilation beneficial to the inflammatory response?
It allows more blood into the injured area.
This means more cells and nutrients are delivered to that area.
Can food and environmental hypersensitivities result in vasodilation?
Yes.
What cardinal signs are caused by vasodilation?
Redness and heat.
Is vasodilation ever responsible for swelling?
No.
What are the 4 ways in which increased vascular permeability can occur?
Increased hydraulic pressure.
Physical mediators.
Direct injury.
Damage cause by white blood cells.
When does increased hydraulic pressure occur?
When there is increased blood within a vessel.
How does increased hydraulic pressure lead to increased vascular permeability?
It forces some fluid out of the vessel and into the extra cellular environment.