08 - muscle and neuromuscular jxn disorders

Question 1

(hereditary disorders)

(canine dystrophin-deficient muscular dystrophy)

1. evident by what age?
2. cx?
3. what in serum is really elevated?

Answer 1

1. 10 to 12 weeks of age
2. stunted grwoth, weakness, muscle atrophy
3. serum creatinine kinase

Question 2

(hereditary disorders)

(feline dystrophin-deficient muscular dystrophy)

1. lethal condition of young male cats
2. Cx?
3. what elevated in serum?

Answer 2

2. skeletal muscle hypertrophy, excess salivation
3. creatinine kinase

Question 3

(hereditary disorders)

(hereditary myopathy of labs)

1. inheritance?
2. Cx?

Answer 3

1. autosomal recessive
2. musc weakness, ex intol, gait abnormalities

Question 4

there are a bunch of these!

Answer 4

Question 5

(acquired neuromuscular disorders)

(autoimmune disorders)

(acquired myasthenia gravis)

1. common in dogs, also occurs in cats
2. autoantibodies against what?
3. leads to what?

Answer 5

2. nicotinic nicotinic acetylcholine receptors on postsynaptic membrane of neuromuscular jxn
3. impaired neuromuscular transmission and weakness

Question 6

what neoplasia is commonly associated with myasthenia gravis and polymyositis?

Answer 6

thymoma

Question 7

Question 8

most common clinical sign?

Answer 8

muscle weakness (and the things that result)

Question 9

(dx)

1. history and px are most important
2. are proprioception and pain usually intact in motor unit disorders?

Answer 9

2. yes

Question 10

(tx)

(generalized myasthenia gravis)

1. what drugs most commonly used for treatment?
2. what is used if this doesn’t work?

Answer 10

1. anticholinesterase drugs
2. corticosteroids

Question 11

(tx for immune mediated inflammatory myopathies)

1. treat with what?

Answer 11

1. immunosuppressive doses of glucocorticoids