06: Serum chem

Question 1

ALT

1. origin?
2. increase means?
3. used in what animals?

Answer 1

1. liver (a little muscle)
2. hepatocellular dmg

mild to mod^: DM, hyperthyroidism (cats), hyperadrenocorticism (dogs), +/- hypothyroidism (dogs)

3. small

Question 2

AST

1. origin?
2. increase means?

Answer 2

1. hepatocytes and skeletal muscle
2. hepatocyte or muscle damage

Question 3

SDH

1. used in?
2. means what?

Answer 3

1. large animals
2. liver dmg

Question 4

creatinine kinase

1. increase means what?

Answer 4

1. muscle damage

only severe^ are indicative of primary muscle disease

Question 5

ALP

1. origin?
2. increase means?

Answer 5

1. hepatocytes, biliary epi, bone
2. post hepatic cholestasis (esp with ^GGT, bilirubin)

drugs/hormones: corticosteroids (dogs), phenobarb

metabolic: hyperthyroidism, hyperadrenocorticism, DM

osteoblastic activity

Question 6

GGT

1. origin?
2. general interp?

Answer 6

1. biliary epi, hepatocytes, renal tubular cells, colostrum
2. post hepatic cholestasis or biliary hyperplasia

drugs/hormones (same as ALP)

colostrum ingestion

Question 7

1. cats may show what with lipidosis?

Answer 7

1. may have high ALP, normal GGT

Question 8

amylase

1. origin?
2. not used in what?
3. general interp?

Answer 8

1. pancreas, intestine, liver
2. cats/LA
3. pancreatic acinar dmg (esp if very high)

GI dz

decreased GFR (2-3X increase)

Question 9

lipase

1. origin?
2. not used in what?
3. interp?

Answer 9

1. pancreatic acinar cells
2. LA
3. pancreatic acinar dmg

dec GFR